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Chronic cryptococcal meningitis: a new experimental model in rabbits.

Publication ,  Journal Article
Perfect, JR; Lang, SD; Durack, DT
Published in: Am J Pathol
October 1980

This paper describes the salient features of a new model for chronic cryptococcal meningitis in cortisone-treated rabbits. Normal rabbits soon recovered after intracisternal inoculation of Cryptococcus neoformans, but cortisone-treated animals developed chronic progressive meningitis that was fatal in 2-12 weeks. Incidence and severity of infection was related to cortisone dose, not to inoculum size. The number of mononuclear cells that migrated into the subarachnoid spaces and cerebrospinal fluid of infected rabbits was strikingly reduced by cortisone treatment. Rabbits with cryptococcal meningitis were febrile; their high body temperature did not confer resistance to this infection. Cortisone-treated rabbits provide a new and expedient laboratory model for cryptococcal disease. Potential applications include study of the pathogenesis of cryptococcosis, investigation of the immunobiology of the CNS in chronic meningitis, and in vivo evaluation of newer anticryptococcal treatment regimens.

Duke Scholars

Published In

Am J Pathol

ISSN

0002-9440

Publication Date

October 1980

Volume

101

Issue

1

Start / End Page

177 / 194

Location

United States

Related Subject Headings

  • Rabbits
  • Pathology
  • Neutrophils
  • Monocytes
  • Meningitis
  • Male
  • Injections, Intramuscular
  • Humans
  • Disease Models, Animal
  • Cryptococcus neoformans
 

Citation

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MLA
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Perfect, J. R., Lang, S. D., & Durack, D. T. (1980). Chronic cryptococcal meningitis: a new experimental model in rabbits. Am J Pathol, 101(1), 177–194.
Perfect, J. R., S. D. Lang, and D. T. Durack. “Chronic cryptococcal meningitis: a new experimental model in rabbits.Am J Pathol 101, no. 1 (October 1980): 177–94.
Perfect JR, Lang SD, Durack DT. Chronic cryptococcal meningitis: a new experimental model in rabbits. Am J Pathol. 1980 Oct;101(1):177–94.
Perfect, J. R., et al. “Chronic cryptococcal meningitis: a new experimental model in rabbits.Am J Pathol, vol. 101, no. 1, Oct. 1980, pp. 177–94.
Perfect JR, Lang SD, Durack DT. Chronic cryptococcal meningitis: a new experimental model in rabbits. Am J Pathol. 1980 Oct;101(1):177–194.
Journal cover image

Published In

Am J Pathol

ISSN

0002-9440

Publication Date

October 1980

Volume

101

Issue

1

Start / End Page

177 / 194

Location

United States

Related Subject Headings

  • Rabbits
  • Pathology
  • Neutrophils
  • Monocytes
  • Meningitis
  • Male
  • Injections, Intramuscular
  • Humans
  • Disease Models, Animal
  • Cryptococcus neoformans