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Comparison of cotrimoxazole, ampicillin, and chloramphenicol in treatment of experimental Haemophilus influenzae type B meningitis.

Publication ,  Journal Article
Perfect, JR; Lang, SD; Durack, DT
Published in: Antimicrob Agents Chemother
January 1980

To evaluate cotrimoxazole in the treatment of bacterial meningitis, we compared its action with that of ampicillin and chloramphenicol in experimental Haemophilus influenzae type b meningitis. Both trimethoprim and sulfamethoxazole penetrated well into the cerebrospinal fluid of infected rabbits, reaching 40 and 26%, respectively, of their simultaneous serum levels. Levels measured 30 and 60 min after intravenous injection exceeded the minimum inhibitory concentration of this combination for H. influenzae by 10- to 100-fold. The mean ratio of trimethoprim to sulfamethoxazole in cerebrospinal fluid was 1:22. Cotrimoxazole was as effective as ampicillin in therapy of beta-lactamase-negative H. influenzae meningitis and as effective as chloramphenicol for a beta-lactamase positive strain. These findings corroborate favorable preliminary clinical experience reported by others and indicate that cotrimoxazole deserves further study in the therapy of bacterial meningitis.

Duke Scholars

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

January 1980

Volume

17

Issue

1

Start / End Page

43 / 48

Location

United States

Related Subject Headings

  • Trimethoprim
  • Time Factors
  • Sulfamethoxazole
  • Rabbits
  • Microbiology
  • Microbial Sensitivity Tests
  • Meningitis, Haemophilus
  • Male
  • Haemophilus influenzae
  • Drug Therapy, Combination
 

Citation

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MLA
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Perfect, J. R., Lang, S. D., & Durack, D. T. (1980). Comparison of cotrimoxazole, ampicillin, and chloramphenicol in treatment of experimental Haemophilus influenzae type B meningitis. Antimicrob Agents Chemother, 17(1), 43–48. https://doi.org/10.1128/AAC.17.1.43
Perfect, J. R., S. D. Lang, and D. T. Durack. “Comparison of cotrimoxazole, ampicillin, and chloramphenicol in treatment of experimental Haemophilus influenzae type B meningitis.Antimicrob Agents Chemother 17, no. 1 (January 1980): 43–48. https://doi.org/10.1128/AAC.17.1.43.
Perfect, J. R., et al. “Comparison of cotrimoxazole, ampicillin, and chloramphenicol in treatment of experimental Haemophilus influenzae type B meningitis.Antimicrob Agents Chemother, vol. 17, no. 1, Jan. 1980, pp. 43–48. Pubmed, doi:10.1128/AAC.17.1.43.

Published In

Antimicrob Agents Chemother

DOI

ISSN

0066-4804

Publication Date

January 1980

Volume

17

Issue

1

Start / End Page

43 / 48

Location

United States

Related Subject Headings

  • Trimethoprim
  • Time Factors
  • Sulfamethoxazole
  • Rabbits
  • Microbiology
  • Microbial Sensitivity Tests
  • Meningitis, Haemophilus
  • Male
  • Haemophilus influenzae
  • Drug Therapy, Combination