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Visualization of neuromuscular junctions over periods of several months in living mice.

Publication ,  Journal Article
Lichtman, JW; Magrassi, L; Purves, D
Published in: The Journal of neuroscience : the official journal of the Society for Neuroscience
April 1987

Identified neuromuscular junctions were followed in the sternomastoid muscle of living mice for several months by repeated staining with the fluorescent dye 4-(4-diethylaminostyryl)-N-methylpyridinium iodide (4-Di-2-ASP; Magrassi et al., 1987). Overall terminal growth occurred at many endplates; however, the branching pattern of presynaptic arbors was largely unchanged, even after several months. The absence of significant remodeling over time was not a result of dye-staining, since sprouting was readily induced at residual motor endings by partial denervation. We conclude that--apart from overall growth--most neuromuscular junctions in the adult mouse are stable over intervals that represent a significant fraction of the animal's lifetime.

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Published In

The Journal of neuroscience : the official journal of the Society for Neuroscience

DOI

EISSN

1529-2401

ISSN

0270-6474

Publication Date

April 1987

Volume

7

Issue

4

Start / End Page

1215 / 1222

Related Subject Headings

  • Pyridinium Compounds
  • Neuromuscular Junction
  • Neurology & Neurosurgery
  • Microscopy, Fluorescence
  • Mice
  • Male
  • Histocytochemistry
  • Fluorescent Dyes
  • Female
  • Animals
 

Citation

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Lichtman, J. W., Magrassi, L., & Purves, D. (1987). Visualization of neuromuscular junctions over periods of several months in living mice. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 7(4), 1215–1222. https://doi.org/10.1523/jneurosci.07-04-01215.1987
Lichtman, J. W., L. Magrassi, and D. Purves. “Visualization of neuromuscular junctions over periods of several months in living mice.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 7, no. 4 (April 1987): 1215–22. https://doi.org/10.1523/jneurosci.07-04-01215.1987.
Lichtman JW, Magrassi L, Purves D. Visualization of neuromuscular junctions over periods of several months in living mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1987 Apr;7(4):1215–22.
Lichtman, J. W., et al. “Visualization of neuromuscular junctions over periods of several months in living mice.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol. 7, no. 4, Apr. 1987, pp. 1215–22. Epmc, doi:10.1523/jneurosci.07-04-01215.1987.
Lichtman JW, Magrassi L, Purves D. Visualization of neuromuscular junctions over periods of several months in living mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1987 Apr;7(4):1215–1222.

Published In

The Journal of neuroscience : the official journal of the Society for Neuroscience

DOI

EISSN

1529-2401

ISSN

0270-6474

Publication Date

April 1987

Volume

7

Issue

4

Start / End Page

1215 / 1222

Related Subject Headings

  • Pyridinium Compounds
  • Neuromuscular Junction
  • Neurology & Neurosurgery
  • Microscopy, Fluorescence
  • Mice
  • Male
  • Histocytochemistry
  • Fluorescent Dyes
  • Female
  • Animals