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Psychophysiological interactions between caffeine and nicotine.

Publication ,  Journal Article
Rose, JE; Behm, FM
Published in: Pharmacol Biochem Behav
February 1991

The interactive effects of caffeine and nicotine were studied in twelve subjects. Mood and physiologic responses to the pharmacologic components nicotine and caffeine were measured, while controlling for the sensory/behavioral aspects of smoking and coffee drinking. Two experimental sessions presented a caffeine x nicotine design, with caffeinated or decaffeinated coffee followed at thirty-minute intervals by controlled inhalations of nicotine and nonnicotine smoke. Results showed that there was a significant interactive effect of caffeine and nicotine on subjective arousal such that nicotine decreased arousal only in the presence of caffeine. These findings extend previous work showing interactive effects of caffeine and self-titrated doses of cigarette smoke in affecting subjective arousal. The effects of nicotine on subjective arousal may, therefore, depend not only on nicotine dose, but also on the presence of caffeine. Heart rate was increased by nicotine and both systolic and diastolic blood pressures were elevated by caffeine. Caffeine also potentiated the increase in diastolic blood pressure resulting from smoke inhalations, but this occurred irrespective of nicotine dose.

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Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

February 1991

Volume

38

Issue

2

Start / End Page

333 / 337

Location

United States

Related Subject Headings

  • Smoking
  • Skin Temperature
  • Personality Tests
  • Nicotine
  • Neurons, Afferent
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Heart Rate
  • Female
 

Citation

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Rose, J. E., & Behm, F. M. (1991). Psychophysiological interactions between caffeine and nicotine. Pharmacol Biochem Behav, 38(2), 333–337. https://doi.org/10.1016/0091-3057(91)90287-c
Rose, J. E., and F. M. Behm. “Psychophysiological interactions between caffeine and nicotine.Pharmacol Biochem Behav 38, no. 2 (February 1991): 333–37. https://doi.org/10.1016/0091-3057(91)90287-c.
Rose JE, Behm FM. Psychophysiological interactions between caffeine and nicotine. Pharmacol Biochem Behav. 1991 Feb;38(2):333–7.
Rose, J. E., and F. M. Behm. “Psychophysiological interactions between caffeine and nicotine.Pharmacol Biochem Behav, vol. 38, no. 2, Feb. 1991, pp. 333–37. Pubmed, doi:10.1016/0091-3057(91)90287-c.
Rose JE, Behm FM. Psychophysiological interactions between caffeine and nicotine. Pharmacol Biochem Behav. 1991 Feb;38(2):333–337.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

February 1991

Volume

38

Issue

2

Start / End Page

333 / 337

Location

United States

Related Subject Headings

  • Smoking
  • Skin Temperature
  • Personality Tests
  • Nicotine
  • Neurons, Afferent
  • Neurology & Neurosurgery
  • Male
  • Humans
  • Heart Rate
  • Female