Skip to main content
Journal cover image

Tar, CO and delta 9THC delivery from the 1st and 2nd halves of a marijuana cigarette.

Publication ,  Journal Article
Tashkin, DP; Gliederer, F; Rose, J; Chang, P; Hui, KK; Yu, JL; Wu, TC
Published in: Pharmacol Biochem Behav
November 1991

Previous in vitro studies suggest that, with successive puffs from a marijuana cigarette, delta-9-THC becomes concentrated in the remaining uncombusted portion of the cigarette. These observations are consistent with the common practice of smoking marijuana cigarettes to a smaller butt length than that to which tobacco cigarettes are smoked. The purpose of the present study was to compare the delivery of delta-9-THC, as well as total insoluble smoke particulates (tar) and carbon monoxide, from the distal ("first") versus the proximal ("second") halves of a standard marijuana cigarette during "natural" smoking of marijuana. On 4 separate days, ten habitual marijuana users smoked nearly all or approximately 1/2 of a standard marijuana cigarette (83 mm length; 800-900 mg; 1.24% THC), as follows: day 1, "whole" cigarette (60 mm smoked, leaving a 23-mm butt); day 2, "first" half (first 30 mm); day 3, "second" half (second 30 mm) after the "first" half was presmoked with a syringe; and day 4, "second" half after the "first" half was excised. A previously described smoking apparatus (20) was used for measurement of puff volume and inhaled tar. Puff volume and number were allowed to vary spontaneously (provided that the specified length of cigarette was consumed), while inhaled volume (1.5 liters), breathholding time (14 s) and interpuff interval (30 s) were held constant. Blood samples were withdrawn prior to smoking and serially after completion of smoking for analysis of blood carboxyhemoglobin (COHb) and serum delta-9-THC. Heart rate was measured before and 5 min after smoking. Subjects rated their level of "high" 20 min after completion of smoking.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

November 1991

Volume

40

Issue

3

Start / End Page

657 / 661

Location

United States

Related Subject Headings

  • Tars
  • Neurology & Neurosurgery
  • Marijuana Smoking
  • Humans
  • Heart Rate
  • Dronabinol
  • Carboxyhemoglobin
  • Carbon Monoxide
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tashkin, D. P., Gliederer, F., Rose, J., Chang, P., Hui, K. K., Yu, J. L., & Wu, T. C. (1991). Tar, CO and delta 9THC delivery from the 1st and 2nd halves of a marijuana cigarette. Pharmacol Biochem Behav, 40(3), 657–661. https://doi.org/10.1016/0091-3057(91)90378-f
Tashkin, D. P., F. Gliederer, J. Rose, P. Chang, K. K. Hui, J. L. Yu, and T. C. Wu. “Tar, CO and delta 9THC delivery from the 1st and 2nd halves of a marijuana cigarette.Pharmacol Biochem Behav 40, no. 3 (November 1991): 657–61. https://doi.org/10.1016/0091-3057(91)90378-f.
Tashkin DP, Gliederer F, Rose J, Chang P, Hui KK, Yu JL, et al. Tar, CO and delta 9THC delivery from the 1st and 2nd halves of a marijuana cigarette. Pharmacol Biochem Behav. 1991 Nov;40(3):657–61.
Tashkin, D. P., et al. “Tar, CO and delta 9THC delivery from the 1st and 2nd halves of a marijuana cigarette.Pharmacol Biochem Behav, vol. 40, no. 3, Nov. 1991, pp. 657–61. Pubmed, doi:10.1016/0091-3057(91)90378-f.
Tashkin DP, Gliederer F, Rose J, Chang P, Hui KK, Yu JL, Wu TC. Tar, CO and delta 9THC delivery from the 1st and 2nd halves of a marijuana cigarette. Pharmacol Biochem Behav. 1991 Nov;40(3):657–661.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

November 1991

Volume

40

Issue

3

Start / End Page

657 / 661

Location

United States

Related Subject Headings

  • Tars
  • Neurology & Neurosurgery
  • Marijuana Smoking
  • Humans
  • Heart Rate
  • Dronabinol
  • Carboxyhemoglobin
  • Carbon Monoxide
  • 1115 Pharmacology and Pharmaceutical Sciences