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Oral contraceptives and breast cancer: A case-control study with hospital and community controls

Publication ,  Journal Article
Schildkraut, JM; Hulka, BS; Wilkinson, WE
Published in: Obstetrics and Gynecology
January 1, 1990

Several recent reports have noted an increased risk of breast cancer associated with the use of oral contraceptives (OCs) among various subgroups of young women. These reports spurred us to analyze data from a case-control study in North Carolina of 158 breast cancer patients, 326 hospital controls, and 1140 community controls less than 60 years of age. A logistic regression model was used to calculate odds ratios and 95% confidence intervals and to control for potential confounders. No association between ever-use of OCs and the risk of breast cancer was found for cases compared with either control group. No increased risk was observed for OC use before age 25 or before first full-term pregnancy, or in relation to duration of use, recency of use, or time since first use. Analysis of the subgroup of women less than 45 years of age also showed no relationship between OC use and breast cancer risk. However, an elevated risk of breast cancer was observed among nulliparous women with 5 or more years of OC use in comparisons with hospital controls (odds ratio 7.8) and community controls (odds ratio 2.3). This analysis was based on small numbers of subjects and the 95% confidence intervals touched or overlapped with 1. An unexpected association between duration of OC use and breast cancer risk was found among older premenopausal women in comparisons of cases with both control groups. For these women, a trend was evident in the odds ratio by duration of OC use, and the comparison between cases and community controls was statistically significant. These data support the bulk of studies showing little association between breast cancer risk and OC use by adult women. © 1990 The American College of Obstetricians and Gynecologists.

Duke Scholars

Published In

Obstetrics and Gynecology

EISSN

1873-233X

ISSN

0029-7844

Publication Date

January 1, 1990

Volume

76

Issue

3

Start / End Page

395 / 402

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • 1114 Paediatrics and Reproductive Medicine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schildkraut, J. M., Hulka, B. S., & Wilkinson, W. E. (1990). Oral contraceptives and breast cancer: A case-control study with hospital and community controls. Obstetrics and Gynecology, 76(3), 395–402.
Schildkraut, J. M., B. S. Hulka, and W. E. Wilkinson. “Oral contraceptives and breast cancer: A case-control study with hospital and community controls.” Obstetrics and Gynecology 76, no. 3 (January 1, 1990): 395–402.
Schildkraut JM, Hulka BS, Wilkinson WE. Oral contraceptives and breast cancer: A case-control study with hospital and community controls. Obstetrics and Gynecology. 1990 Jan 1;76(3):395–402.
Schildkraut, J. M., et al. “Oral contraceptives and breast cancer: A case-control study with hospital and community controls.” Obstetrics and Gynecology, vol. 76, no. 3, Jan. 1990, pp. 395–402.
Schildkraut JM, Hulka BS, Wilkinson WE. Oral contraceptives and breast cancer: A case-control study with hospital and community controls. Obstetrics and Gynecology. 1990 Jan 1;76(3):395–402.

Published In

Obstetrics and Gynecology

EISSN

1873-233X

ISSN

0029-7844

Publication Date

January 1, 1990

Volume

76

Issue

3

Start / End Page

395 / 402

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • 1114 Paediatrics and Reproductive Medicine