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Transport pathways in rat lingual epithelium.

Publication ,  Journal Article
Simon, SA; Robb, R; Schiffman, SS
Published in: Pharmacol Biochem Behav
February 1988

Measurements of ion transport across isolated lingual epithelium of rat were correlated with electrophysiological recordings from taste nerves. At hyperosmotic concentrations of NaCl, sodium ions enter the mucosal membrane of the isolated epithelium partially through an amiloride-inhibitable pathway and exit the serosal membrane through a Na+-K+-ATPase. At hyposmotic concentrations of KCl, potassium ions enter the mucosal membrane through a K+ pathway that is inhibited by 4-aminopyridine and exit at the serosal membrane through a K+ pathway that is inhibited by BaCl2. The inhibition of sodium transport by amiloride and potassium transport by 4-aminopyridine is consistent with previously published electrophysiological recordings from the chorda tympani nerve bundle (CT) and recordings from nucleus of the solitary tract (NST) obtained here. The responses to NaCl are greater than the responses to KCl at equimolar concentrations over the entire concentration range both in epithelial and neural measurements. At hyposmotic concentrations of NaCl the epithelial responses include inward sodium and outward chloride components. Isolated rat tongue is only slightly stimulated by D-glucose or sucrose as are the CT and NTS responses. These data suggest that events in taste transduction can be understood, in part, by measuring the epithelial responses of isolated rat tongue.

Duke Scholars

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

February 1988

Volume

29

Issue

2

Start / End Page

257 / 267

Location

United States

Related Subject Headings

  • Tongue
  • Sucrose
  • Sodium Chloride
  • Rats, Inbred Strains
  • Rats
  • Potassium Chloride
  • Osmosis
  • Neurology & Neurosurgery
  • Membrane Potentials
  • In Vitro Techniques
 

Citation

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Simon, S. A., Robb, R., & Schiffman, S. S. (1988). Transport pathways in rat lingual epithelium. Pharmacol Biochem Behav, 29(2), 257–267. https://doi.org/10.1016/0091-3057(88)90154-2
Simon, S. A., R. Robb, and S. S. Schiffman. “Transport pathways in rat lingual epithelium.Pharmacol Biochem Behav 29, no. 2 (February 1988): 257–67. https://doi.org/10.1016/0091-3057(88)90154-2.
Simon SA, Robb R, Schiffman SS. Transport pathways in rat lingual epithelium. Pharmacol Biochem Behav. 1988 Feb;29(2):257–67.
Simon, S. A., et al. “Transport pathways in rat lingual epithelium.Pharmacol Biochem Behav, vol. 29, no. 2, Feb. 1988, pp. 257–67. Pubmed, doi:10.1016/0091-3057(88)90154-2.
Simon SA, Robb R, Schiffman SS. Transport pathways in rat lingual epithelium. Pharmacol Biochem Behav. 1988 Feb;29(2):257–267.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

February 1988

Volume

29

Issue

2

Start / End Page

257 / 267

Location

United States

Related Subject Headings

  • Tongue
  • Sucrose
  • Sodium Chloride
  • Rats, Inbred Strains
  • Rats
  • Potassium Chloride
  • Osmosis
  • Neurology & Neurosurgery
  • Membrane Potentials
  • In Vitro Techniques