Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.
Publication
, Journal Article
Mercola, M; Wang, XF; Olsen, J; Calame, K
Published in: Science
August 12, 1983
Two regions in the immunoglobulin heavy chain locus were tested for their ability to enhance transcription of the SV40 early promoter. A portion of the intervening sequence between the heavy chain joining region (Jh) and the constant region of the mu chain (Cmu) can enhance transcription when it is cloned either 5' or 3' to the SV40 early promoter. The region between C alpha and the alpha switch site, which occurs 5' to the translocated c-myc oncogene in many murine plasmacytomas, does not show transcriptional enhancer activity in this assay.
Duke Scholars
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
August 12, 1983
Volume
221
Issue
4611
Start / End Page
663 / 665
Location
United States
Related Subject Headings
- Transfection
- Transcription, Genetic
- Simian virus 40
- Operon
- Mice
- Immunoglobulin Heavy Chains
- Genetic Vectors
- General Science & Technology
- Gene Expression Regulation
- Cloning, Molecular
Citation
APA
Chicago
ICMJE
MLA
NLM
Mercola, M., Wang, X. F., Olsen, J., & Calame, K. (1983). Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus. Science, 221(4611), 663–665. https://doi.org/10.1126/science.6306772
Mercola, M., X. F. Wang, J. Olsen, and K. Calame. “Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.” Science 221, no. 4611 (August 12, 1983): 663–65. https://doi.org/10.1126/science.6306772.
Mercola M, Wang XF, Olsen J, Calame K. Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus. Science. 1983 Aug 12;221(4611):663–5.
Mercola, M., et al. “Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.” Science, vol. 221, no. 4611, Aug. 1983, pp. 663–65. Pubmed, doi:10.1126/science.6306772.
Mercola M, Wang XF, Olsen J, Calame K. Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus. Science. 1983 Aug 12;221(4611):663–665.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
August 12, 1983
Volume
221
Issue
4611
Start / End Page
663 / 665
Location
United States
Related Subject Headings
- Transfection
- Transcription, Genetic
- Simian virus 40
- Operon
- Mice
- Immunoglobulin Heavy Chains
- Genetic Vectors
- General Science & Technology
- Gene Expression Regulation
- Cloning, Molecular