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Homogeneous NMR spectra in inhomogeneous fields.

Publication ,  Journal Article
Vathyam, S; Lee, S; Warren, WS
Published in: Science (New York, N.Y.)
April 1996

Researchers interested in high-resolution nuclear magnetic resonance (NMR) spectroscopy have long sought higher magnetic fields to enhance resolution and simplify spectra. Magnets with substantially larger fields than those available in the best commercial spectrometers are available, but the inhomogeneity is unacceptable for high-resolution spectra. A detection method (termed HOMOGENIZED) is presented that removes inhomogeneity while retaining chemical shift differences and J couplings. With existing inhomogeneous magnets, this method could nearly double the largest resonance frequency available for high-resolution NMR. The HOMOGENIZED sequence is based on observations of intermolecular zero-quantum coherences between a solute molecule and solvent molecules that are micrometers away; as long as the field is homogeneous over this short distance, sharp resonances are recovered without echoes. Experimental demonstrations and a detailed density matrix theory to explain the effect are presented.

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Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

April 1996

Volume

272

Issue

5258

Start / End Page

92 / 96

Related Subject Headings

  • Solvents
  • Proteins
  • Mathematics
  • Magnetic Resonance Spectroscopy
  • General Science & Technology
  • Aprotinin
 

Citation

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Vathyam, S., Lee, S., & Warren, W. S. (1996). Homogeneous NMR spectra in inhomogeneous fields. Science (New York, N.Y.), 272(5258), 92–96. https://doi.org/10.1126/science.272.5258.92
Vathyam, S., S. Lee, and W. S. Warren. “Homogeneous NMR spectra in inhomogeneous fields.Science (New York, N.Y.) 272, no. 5258 (April 1996): 92–96. https://doi.org/10.1126/science.272.5258.92.
Vathyam S, Lee S, Warren WS. Homogeneous NMR spectra in inhomogeneous fields. Science (New York, NY). 1996 Apr;272(5258):92–6.
Vathyam, S., et al. “Homogeneous NMR spectra in inhomogeneous fields.Science (New York, N.Y.), vol. 272, no. 5258, Apr. 1996, pp. 92–96. Epmc, doi:10.1126/science.272.5258.92.
Vathyam S, Lee S, Warren WS. Homogeneous NMR spectra in inhomogeneous fields. Science (New York, NY). 1996 Apr;272(5258):92–96.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

April 1996

Volume

272

Issue

5258

Start / End Page

92 / 96

Related Subject Headings

  • Solvents
  • Proteins
  • Mathematics
  • Magnetic Resonance Spectroscopy
  • General Science & Technology
  • Aprotinin