Mammary Carcinogenesis In Rats Fed Different Amounts And Types Of Fat

Rats fed 20% corn oil or lard showed increased 7,12-di-methylbenzanthracene-induced mammary tumorigenesis and slightly increased growth rate compared to rats fed 5% fat; 20% corn oil accelerated sexual maturation, but 20% lard did not. In contrast, diets high in beef fat (30%) depressed tumor induction by 7,12-dimethylbenzanthracene or N-fluorenylacetamide compared to a diet containing 15% vegetable oil; dietary lipotrope content had no effect on tumorigenesis. Further studies are needed of the effects of type and amount of dietary fat on mammary tumorigenesis in several model systems. 9, 2016. © 1981, American Association for Cancer Research. All rights reserved.

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Author William Christopher Wetsel Psychiatry & Behavioral Sciences, Behavioral Medicine & Neur ...