Skip to main content
Journal cover image

Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis.

Publication ,  Journal Article
Hor, KN; Gottliebson, WM; Carson, C; Wash, E; Cnota, J; Fleck, R; Wansapura, J; Klimeczek, P; Al-Khalidi, HR; Chung, ES; Benson, DW; Mazur, W
Published in: JACC Cardiovasc Imaging
February 2010

OBJECTIVES: To compare a steady-state free precession cine sequence-based technique (feature tracking [FT]) to tagged harmonic phase (HARP) analysis for peak average circumferential myocardial strain (epsilon(cc)) analysis in a large and heterogeneous population of boys with Duchenne muscular dystrophy (DMD). BACKGROUND: Current epsilon(cc) assessment techniques require cardiac magnetic resonance-tagged imaging sequences, and their analysis is complex. The FT method can readily be performed on standard cine (steady-state free precession) sequences. METHODS: We compared mid-left ventricular whole-slice epsilon(cc) by the 2 techniques in 191 DMD patients grouped according to age and severity of cardiac dysfunction: group B: DMD patients 10 years and younger with normal ejection fraction (EF); group C: DMD patients older than 10 years with normal EF; group D: DMD patients older than 10 years with reduced EF but negative myocardial delayed enhancement (MDE); group E: DMD patients older than 10 years with reduced EF and positive MDE; and group A: 42 control subjects. Retrospective, offline analysis was performed on matched tagged and steady-state free precession slices. RESULTS: For the entire study population (N = 233), mean FT epsilon(cc) values (-13.3 +/- 3.8%) were highly correlated with HARP epsilon(cc) values (-13.6 +/- 3.4%), with a Pearson correlation coefficient of 0.899. The mean epsilon(cc) of DMD patients determined by HARP (-12.52 +/- 2.69%) and FT (-12.16 +/- 3.12%) was not significantly different (p = NS). Similarly, the mean epsilon(cc) of the control subjects by determined HARP (-18.85 +/- 1.86) and FT (-18.81 +/- 1.83) was not significantly different (p = NS). Excellent correlation between the 2 methods was found among subgroups A through E, except there was no significant difference in strain between groups B and C with FT analysis. CONCLUSIONS: FT-based assessment of epsilon(cc) correlates highly with epsilon(cc) derived from tagged images in a large DMD patient population with a wide range of cardiac dysfunction and can be performed without additional imaging.

Duke Scholars

Published In

JACC Cardiovasc Imaging

DOI

EISSN

1876-7591

Publication Date

February 2010

Volume

3

Issue

2

Start / End Page

144 / 151

Location

United States

Related Subject Headings

  • Young Adult
  • Ventricular Function, Left
  • Time Factors
  • Stroke Volume
  • Severity of Illness Index
  • Retrospective Studies
  • Reproducibility of Results
  • Predictive Value of Tests
  • Myocardial Contraction
  • Muscular Dystrophy, Duchenne
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hor, K. N., Gottliebson, W. M., Carson, C., Wash, E., Cnota, J., Fleck, R., … Mazur, W. (2010). Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis. JACC Cardiovasc Imaging, 3(2), 144–151. https://doi.org/10.1016/j.jcmg.2009.11.006
Hor, Kan N., William M. Gottliebson, Christopher Carson, Erin Wash, James Cnota, Robert Fleck, Janaka Wansapura, et al. “Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis.JACC Cardiovasc Imaging 3, no. 2 (February 2010): 144–51. https://doi.org/10.1016/j.jcmg.2009.11.006.
Hor KN, Gottliebson WM, Carson C, Wash E, Cnota J, Fleck R, et al. Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis. JACC Cardiovasc Imaging. 2010 Feb;3(2):144–51.
Hor, Kan N., et al. “Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis.JACC Cardiovasc Imaging, vol. 3, no. 2, Feb. 2010, pp. 144–51. Pubmed, doi:10.1016/j.jcmg.2009.11.006.
Hor KN, Gottliebson WM, Carson C, Wash E, Cnota J, Fleck R, Wansapura J, Klimeczek P, Al-Khalidi HR, Chung ES, Benson DW, Mazur W. Comparison of magnetic resonance feature tracking for strain calculation with harmonic phase imaging analysis. JACC Cardiovasc Imaging. 2010 Feb;3(2):144–151.
Journal cover image

Published In

JACC Cardiovasc Imaging

DOI

EISSN

1876-7591

Publication Date

February 2010

Volume

3

Issue

2

Start / End Page

144 / 151

Location

United States

Related Subject Headings

  • Young Adult
  • Ventricular Function, Left
  • Time Factors
  • Stroke Volume
  • Severity of Illness Index
  • Retrospective Studies
  • Reproducibility of Results
  • Predictive Value of Tests
  • Myocardial Contraction
  • Muscular Dystrophy, Duchenne