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Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae.

Publication ,  Journal Article
Bagnat, M; Simons, K
Published in: Biol Chem
October 2002

Cellular membranes contain many types and species of lipids. One of the most important functional consequences of this heterogeneity is the existence of microdomains within the plane of the membrane. Sphingolipid acyl chains have the ability of forming tightly packed platforms together with sterols. These platforms or lipid rafts constitute segregation and sorting devices into which proteins specifically associate. In budding yeast, Saccharomyces cerevisiae, lipid rafts serve as sorting platforms for proteins destined to the cell surface. The segregation capacity of rafts also provides the basis for the polarization of proteins at the cell surface during mating. Here we discuss some recent findings that stress the role of lipid rafts as key players in yeast protein sorting and cell polarity.

Duke Scholars

Published In

Biol Chem

DOI

ISSN

1431-6730

Publication Date

October 2002

Volume

383

Issue

10

Start / End Page

1475 / 1480

Location

Germany

Related Subject Headings

  • Signal Transduction
  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • Protein Transport
  • Models, Molecular
  • Membrane Proteins
  • Membrane Microdomains
  • Lipid Metabolism
  • Glycosphingolipids
  • Endoplasmic Reticulum
 

Citation

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Bagnat, M., & Simons, K. (2002). Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. Biol Chem, 383(10), 1475–1480. https://doi.org/10.1515/BC.2002.169
Bagnat, Michel, and Kai Simons. “Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae.Biol Chem 383, no. 10 (October 2002): 1475–80. https://doi.org/10.1515/BC.2002.169.
Bagnat, Michel, and Kai Simons. “Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae.Biol Chem, vol. 383, no. 10, Oct. 2002, pp. 1475–80. Pubmed, doi:10.1515/BC.2002.169.
Bagnat M, Simons K. Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. Biol Chem. 2002 Oct;383(10):1475–1480.
Journal cover image

Published In

Biol Chem

DOI

ISSN

1431-6730

Publication Date

October 2002

Volume

383

Issue

10

Start / End Page

1475 / 1480

Location

Germany

Related Subject Headings

  • Signal Transduction
  • Saccharomyces cerevisiae Proteins
  • Saccharomyces cerevisiae
  • Protein Transport
  • Models, Molecular
  • Membrane Proteins
  • Membrane Microdomains
  • Lipid Metabolism
  • Glycosphingolipids
  • Endoplasmic Reticulum