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Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding.

Publication ,  Journal Article
Dunn-Meynell, AA; Sanders, NM; Compton, D; Becker, TC; Eiki, J-I; Zhang, BB; Levin, BE
Published in: J Neurosci
May 27, 2009

Although several studies implicate small declines in blood glucose levels as stimulus for spontaneous meal initiation, no mechanism is known for how these dips might initiate feeding. To assess the role of ventromedial hypothalamus (VMH) (arcuate plus ventromedial nucleus) glucosensing neurons as potential mediators of spontaneous and glucoprivic feeding, meal patterns were observed, and blood and VMH microdialysis fluid were sampled in 15 rats every 10 min for 3.5 h after dark onset and 2 h after insulin (5 U/kg, i.v.) infusion. Blood glucose levels declined by 11% beginning approximately 5 min before 65% of all spontaneous meals, with no fall in VMH levels. After insulin, blood and VMH glucose reached nadirs by 30-40 min, and the same rats ate 60% faster and spent 84% more time eating during the ensuing hypoglycemia. Although 83% of first hypoglycemic meals were preceded by 5 min dips in VMH (but not blood) glucose levels, neither blood nor VMH levels declined before second meals, suggesting that low glucose, rather than changing levels, was the stimulus for glucoprivic meals. Furthermore, altering VMH glucosensing by raising or lowering glucokinase (GK) activity failed to affect spontaneous feeding, body or adipose weights, or glucose tolerance. However, chronic depletion by 26-70% of VMH GK mRNA reduced glucoprivic feeding. Thus, although VMH glucosensing does not appear to be involved in either spontaneous feeding or long-term body-weight regulation, it does participate in glucoprivic feeding, similar to its role in the counter-regulatory neurohumoral responses to glucoprivation.

Duke Scholars

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

May 27, 2009

Volume

29

Issue

21

Start / End Page

7015 / 7022

Location

United States

Related Subject Headings

  • Ventromedial Hypothalamic Nucleus
  • Time Factors
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Neurology & Neurosurgery
  • Microdialysis
  • Male
  • Insulin
  • Hypoglycemic Agents
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dunn-Meynell, A. A., Sanders, N. M., Compton, D., Becker, T. C., Eiki, J.-I., Zhang, B. B., & Levin, B. E. (2009). Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding. J Neurosci, 29(21), 7015–7022. https://doi.org/10.1523/JNEUROSCI.0334-09.2009
Dunn-Meynell, Ambrose A., Nicole M. Sanders, Douglas Compton, Thomas C. Becker, Jun-ichi Eiki, Bei B. Zhang, and Barry E. Levin. “Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding.J Neurosci 29, no. 21 (May 27, 2009): 7015–22. https://doi.org/10.1523/JNEUROSCI.0334-09.2009.
Dunn-Meynell AA, Sanders NM, Compton D, Becker TC, Eiki J-I, Zhang BB, et al. Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding. J Neurosci. 2009 May 27;29(21):7015–22.
Dunn-Meynell, Ambrose A., et al. “Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding.J Neurosci, vol. 29, no. 21, May 2009, pp. 7015–22. Pubmed, doi:10.1523/JNEUROSCI.0334-09.2009.
Dunn-Meynell AA, Sanders NM, Compton D, Becker TC, Eiki J-I, Zhang BB, Levin BE. Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding. J Neurosci. 2009 May 27;29(21):7015–7022.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

May 27, 2009

Volume

29

Issue

21

Start / End Page

7015 / 7022

Location

United States

Related Subject Headings

  • Ventromedial Hypothalamic Nucleus
  • Time Factors
  • Rats, Sprague-Dawley
  • Rats
  • RNA, Messenger
  • Neurology & Neurosurgery
  • Microdialysis
  • Male
  • Insulin
  • Hypoglycemic Agents