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Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer.

Publication ,  Journal Article
Berek, JS; Chalas, E; Edelson, M; Moore, DH; Burke, WM; Cliby, WA; Berchuck, A; Society of Gynecologic Oncologists Clinical Practice Committee,
Published in: Obstet Gynecol
September 2010

Women who do not have a documented germline mutation or who do not have a strong family history suspicious for a germline mutation are considered to be at average risk of ovarian cancer. Women who have confirmed deleterious BRCA1 and BRCA2 germline mutations are high risk of ovarian cancer. In addition, women who have a strong family history of either ovarian or breast cancer may carry a deleterious mutation and must be presumed to be at higher-than-average risk, even if they have not been tested, because there could be other mutations that are either untested or yet undiscovered that confirm higher-than-average risk of these diseases. We reviewed studies pertaining to prophylactic bilateral salpingo-oophorectomy in women at average risk of ovarian cancer who are undergoing hysterectomy for benign disease. We also reviewed the role of prophylactic bilateral salpingo-oophorectomy in preventing ovarian cancer based on the level of risk of the patient. For women at average risk of ovarian cancer who are undergoing a hysterectomy for benign conditions, the decision to perform prophylactic bilateral salpingo-oophorectomy should be individualized after appropriate informed consent, including a careful analysis of personal risk factors. Several studies suggest an overall negative health effect when prophylactic bilateral salpingo-oophorectomy is performed before the age of menopause. Ovarian conservation before menopause may be especially important in patients with a personal or strong family history of cardiovascular or neurological disease. Conversely, women at high risk of ovarian cancer should undergo risk-reducing bilateral salpingo-oophorectomy.

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Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

September 2010

Volume

116

Issue

3

Start / End Page

733 / 743

Location

United States

Related Subject Headings

  • Risk Factors
  • Reoperation
  • Premenopause
  • Ovariectomy
  • Ovarian Neoplasms
  • Obstetrics & Reproductive Medicine
  • Hysterectomy
  • Humans
  • Germ-Line Mutation
  • Genes, BRCA2
 

Citation

APA
Chicago
ICMJE
MLA
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Berek, J. S., Chalas, E., Edelson, M., Moore, D. H., Burke, W. M., Cliby, W. A., … Society of Gynecologic Oncologists Clinical Practice Committee, . (2010). Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer. Obstet Gynecol, 116(3), 733–743. https://doi.org/10.1097/AOG.0b013e3181ec5fc1
Berek, Jonathan S., Eva Chalas, Mitchell Edelson, David H. Moore, William M. Burke, William A. Cliby, Andrew Berchuck, and Andrew Society of Gynecologic Oncologists Clinical Practice Committee. “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer.Obstet Gynecol 116, no. 3 (September 2010): 733–43. https://doi.org/10.1097/AOG.0b013e3181ec5fc1.
Berek JS, Chalas E, Edelson M, Moore DH, Burke WM, Cliby WA, et al. Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer. Obstet Gynecol. 2010 Sep;116(3):733–43.
Berek, Jonathan S., et al. “Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer.Obstet Gynecol, vol. 116, no. 3, Sept. 2010, pp. 733–43. Pubmed, doi:10.1097/AOG.0b013e3181ec5fc1.
Berek JS, Chalas E, Edelson M, Moore DH, Burke WM, Cliby WA, Berchuck A, Society of Gynecologic Oncologists Clinical Practice Committee. Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer. Obstet Gynecol. 2010 Sep;116(3):733–743.

Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

September 2010

Volume

116

Issue

3

Start / End Page

733 / 743

Location

United States

Related Subject Headings

  • Risk Factors
  • Reoperation
  • Premenopause
  • Ovariectomy
  • Ovarian Neoplasms
  • Obstetrics & Reproductive Medicine
  • Hysterectomy
  • Humans
  • Germ-Line Mutation
  • Genes, BRCA2