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Pretransplant predictors of recovery of renal function after liver transplantation.

Publication ,  Journal Article
Northup, PG; Argo, CK; Bakhru, MR; Schmitt, TM; Berg, CL; Rosner, MH
Published in: Liver Transpl
April 2010

The Model for End-Stage Liver Disease system has given priority on the liver transplant waiting list to candidates with renal failure. This study determined the predictors of spontaneous recovery of renal function after transplantation in 1041 liver transplant recipients on renal replacement therapy (RRT) at the time of transplant (from February 2002 to January 2007). Data from these patients were obtained from the US Organ Procurement and Transplantation Network and US Renal Data System databases. Univariate and multivariate survival models were constructed along with multivariate logistic regression models to find independent predictors of spontaneous renal recovery. Seven hundred seven recipients (67.9%) had spontaneous recovery of renal function after liver transplantation. Those recovering spontaneously had a significantly shorter course of RRT in the pretransplant time period (15.6 versus 36.6 days, P < 0.001). Recovery of renal function was observed in 70.8% and 11.5% of recipients on RRT for less than 30 days and more than 90 days, respectively. Other statistically significant pretransplant variables independently associated with recovery of renal function included recipient age, recipient pretransplant diabetes, and donor age. In conclusion, the duration of pretransplant RRT is highly predictive of spontaneous renal recovery post-transplant. Liver transplant candidates requiring less than 30 days of pretransplant RRT are likely to spontaneously recover renal function after liver transplantation, whereas those on RRT for more than 90 days are not.

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Published In

Liver Transpl

DOI

EISSN

1527-6473

Publication Date

April 2010

Volume

16

Issue

4

Start / End Page

440 / 446

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tissue and Organ Procurement
  • Surgery
  • Registries
  • Models, Theoretical
  • Middle Aged
  • Male
  • Liver Transplantation
  • Liver Failure
  • Kidney Diseases
 

Citation

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ICMJE
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Northup, P. G., Argo, C. K., Bakhru, M. R., Schmitt, T. M., Berg, C. L., & Rosner, M. H. (2010). Pretransplant predictors of recovery of renal function after liver transplantation. Liver Transpl, 16(4), 440–446. https://doi.org/10.1002/lt.22008
Northup, Patrick G., Curtis K. Argo, Mihir R. Bakhru, Timothy M. Schmitt, Carl L. Berg, and Mitchell H. Rosner. “Pretransplant predictors of recovery of renal function after liver transplantation.Liver Transpl 16, no. 4 (April 2010): 440–46. https://doi.org/10.1002/lt.22008.
Northup PG, Argo CK, Bakhru MR, Schmitt TM, Berg CL, Rosner MH. Pretransplant predictors of recovery of renal function after liver transplantation. Liver Transpl. 2010 Apr;16(4):440–6.
Northup, Patrick G., et al. “Pretransplant predictors of recovery of renal function after liver transplantation.Liver Transpl, vol. 16, no. 4, Apr. 2010, pp. 440–46. Pubmed, doi:10.1002/lt.22008.
Northup PG, Argo CK, Bakhru MR, Schmitt TM, Berg CL, Rosner MH. Pretransplant predictors of recovery of renal function after liver transplantation. Liver Transpl. 2010 Apr;16(4):440–446.
Journal cover image

Published In

Liver Transpl

DOI

EISSN

1527-6473

Publication Date

April 2010

Volume

16

Issue

4

Start / End Page

440 / 446

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Tissue and Organ Procurement
  • Surgery
  • Registries
  • Models, Theoretical
  • Middle Aged
  • Male
  • Liver Transplantation
  • Liver Failure
  • Kidney Diseases