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Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma.

Publication ,  Journal Article
Palmer, SL; Hassall, T; Evankovich, K; Mabbott, DJ; Bonner, M; Deluca, C; Cohn, R; Fisher, MJ; Morris, EB; Broniscer, A; Gajjar, A
Published in: Neuro Oncol
December 2010

The aim is to prospectively assess early neurocognitive outcome of children who developed cerebellar mutism syndrome (CMS) following surgical resection of a posterior fossa embryonal tumor, compared with carefully matched control patients. Children who were enrolled on an ongoing IRB-approved protocol for treatment of embryonal tumors, were diagnosed with postoperative CMS, and had completed prospectively planned neuropsychological evaluation at 12 months postdiagnosis were considered eligible. The cognitive outcomes of these patients were examined in comparison to patients without CMS from the same treatment protocol and matched with regard to primary diagnosis, age at diagnosis, and risk/corresponding treatment (n = 22 pairs). Seventeen were also matched according to gender, and 14 were also matched according to race. High-risk patients received 36-39.6 Gy CSI and 3D conformal boost to the primary site to 55.8-59.4 Gy. Average-risk patients received 23.4 Gy CSI and 3D conformal boost to the primary site to 55.8 Gy. Significant group differences were found on multiple cognitive outcomes. While the matched control patients exhibited performance in the average range, patients who developed CMS postsurgery were found to have significantly lower performance in processing speed, attention, working memory, executive processes, cognitive efficiency, reading, spelling, and math. Patients treated for medulloblastoma who experience postoperative CMS show an increased risk for neurocognitive impairment, evident as early as 12 months following diagnosis. This study highlights the need for careful follow-up with neuropsychological evaluation and for obtaining critical support for patients and their families.

Duke Scholars

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

December 2010

Volume

12

Issue

12

Start / End Page

1311 / 1317

Location

England

Related Subject Headings

  • Vincristine
  • Treatment Outcome
  • Time Factors
  • Survival Rate
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Neuropsychological Tests
  • Mutism
  • Medulloblastoma
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Palmer, S. L., Hassall, T., Evankovich, K., Mabbott, D. J., Bonner, M., Deluca, C., … Gajjar, A. (2010). Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. Neuro Oncol, 12(12), 1311–1317. https://doi.org/10.1093/neuonc/noq094
Palmer, Shawna L., Tim Hassall, Karen Evankovich, Donald J. Mabbott, Melanie Bonner, Cinzia Deluca, Richard Cohn, et al. “Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma.Neuro Oncol 12, no. 12 (December 2010): 1311–17. https://doi.org/10.1093/neuonc/noq094.
Palmer SL, Hassall T, Evankovich K, Mabbott DJ, Bonner M, Deluca C, et al. Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. Neuro Oncol. 2010 Dec;12(12):1311–7.
Palmer, Shawna L., et al. “Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma.Neuro Oncol, vol. 12, no. 12, Dec. 2010, pp. 1311–17. Pubmed, doi:10.1093/neuonc/noq094.
Palmer SL, Hassall T, Evankovich K, Mabbott DJ, Bonner M, Deluca C, Cohn R, Fisher MJ, Morris EB, Broniscer A, Gajjar A. Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. Neuro Oncol. 2010 Dec;12(12):1311–1317.
Journal cover image

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

December 2010

Volume

12

Issue

12

Start / End Page

1311 / 1317

Location

England

Related Subject Headings

  • Vincristine
  • Treatment Outcome
  • Time Factors
  • Survival Rate
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Neuropsychological Tests
  • Mutism
  • Medulloblastoma
  • Male