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Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma.

Publication ,  Journal Article
Lee, WT; Yoo, DS; Puscas, L; Witsell, D; Cohen, SM; Fisher, SR; Scher, R; Broadwater, G; Ready, N; Brizel, DR; Esclamado, RM
Published in: Head Neck
June 2012

BACKGROUND: As multidisciplinary cancer treatment evolves, strategies to identify patients needing early resection/salvage are necessary. Some have suggested that vocal cord function after organ-preservation treatment may be an indicator. METHODS: A retrospective review was performed of patients presenting with fixed or impaired vocal cord function at a tertiary center. Local recurrence rates were examined in patients with and without improved/normal mobilization after treatment. RESULTS: Sixty-nine patients met the inclusion criteria, with 35 patients having vocal cord fixation and 34 patients with impaired mobility. After treatment, 44 patients had normalization of vocal cord function, while 25 patients did not, with 2-year local control rates of 70% and 77%, p = .23, respectively. No difference in local control was found between patients with normalized/improved cord function (n = 53) and those who remained the same/worsened (n = 16; p = .81). CONCLUSION: Therapy-induced changes in vocal cord mobility did not correlate with local recurrence. Other criteria are needed to identify patients most likely to benefit from early surgical resection/salvage after organ preservation.

Duke Scholars

Published In

Head Neck

DOI

EISSN

1097-0347

Publication Date

June 2012

Volume

34

Issue

6

Start / End Page

792 / 796

Location

United States

Related Subject Headings

  • Vocal Cord Paralysis
  • Retrospective Studies
  • Radiotherapy, Adjuvant
  • Otorhinolaryngology
  • Organ Sparing Treatments
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Laryngeal Neoplasms
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, W. T., Yoo, D. S., Puscas, L., Witsell, D., Cohen, S. M., Fisher, S. R., … Esclamado, R. M. (2012). Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma. Head Neck, 34(6), 792–796. https://doi.org/10.1002/hed.21813
Lee, Walter T., David S. Yoo, Liana Puscas, David Witsell, Seth M. Cohen, Samuel R. Fisher, Richard Scher, et al. “Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma.Head Neck 34, no. 6 (June 2012): 792–96. https://doi.org/10.1002/hed.21813.
Lee WT, Yoo DS, Puscas L, Witsell D, Cohen SM, Fisher SR, et al. Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma. Head Neck. 2012 Jun;34(6):792–6.
Lee, Walter T., et al. “Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma.Head Neck, vol. 34, no. 6, June 2012, pp. 792–96. Pubmed, doi:10.1002/hed.21813.
Lee WT, Yoo DS, Puscas L, Witsell D, Cohen SM, Fisher SR, Scher R, Broadwater G, Ready N, Brizel DR, Esclamado RM. Treatment-induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma. Head Neck. 2012 Jun;34(6):792–796.
Journal cover image

Published In

Head Neck

DOI

EISSN

1097-0347

Publication Date

June 2012

Volume

34

Issue

6

Start / End Page

792 / 796

Location

United States

Related Subject Headings

  • Vocal Cord Paralysis
  • Retrospective Studies
  • Radiotherapy, Adjuvant
  • Otorhinolaryngology
  • Organ Sparing Treatments
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Laryngeal Neoplasms
  • Humans