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Cushing's disease. A review.

Publication ,  Journal Article
Burch, WM
Published in: Arch Intern Med
June 1985

Cushing's syndrome continues to tax the most discerning clinician. I review pituitary-dependent adrenal hyperplasia (Cushing's disease), including recent experiences with Cushing's disease at Duke University, Durham, NC, and relate these observations to the current ideas as to pathophysiology, etiology, and management of Cushing's disease. Transsphenoidal microsurgery (TPS) performed by an experienced neurosurgeon offers selective removal of corticotropin (ACTH)-secreting adenoma, immediately cures the hypercortisolism, preserves pituitary function, and is associated with minimal morbidity. Postoperative hypoadrenalism appears to be the best marker of surgical cure. Transsphenoidal surgery has revolutionized our thoughts as to etiology and treatment of Cushing's disease, yet failures with TPS and uncertainty of recurrences leave room for radiotherapy, adrenalectomy, and adjunctive drug therapy in the management of this entity.

Duke Scholars

Published In

Arch Intern Med

ISSN

0003-9926

Publication Date

June 1985

Volume

145

Issue

6

Start / End Page

1106 / 1111

Location

United States

Related Subject Headings

  • Valproic Acid
  • Sella Turcica
  • Reserpine
  • Recurrence
  • Radiotherapy
  • Prognosis
  • Pituitary Neoplasms
  • Middle Aged
  • Microsurgery
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Burch, W. M. (1985). Cushing's disease. A review. Arch Intern Med, 145(6), 1106–1111.
Burch, W. M. “Cushing's disease. A review.Arch Intern Med 145, no. 6 (June 1985): 1106–11.
Burch WM. Cushing's disease. A review. Arch Intern Med. 1985 Jun;145(6):1106–11.
Burch, W. M. “Cushing's disease. A review.Arch Intern Med, vol. 145, no. 6, June 1985, pp. 1106–11.
Burch WM. Cushing's disease. A review. Arch Intern Med. 1985 Jun;145(6):1106–1111.

Published In

Arch Intern Med

ISSN

0003-9926

Publication Date

June 1985

Volume

145

Issue

6

Start / End Page

1106 / 1111

Location

United States

Related Subject Headings

  • Valproic Acid
  • Sella Turcica
  • Reserpine
  • Recurrence
  • Radiotherapy
  • Prognosis
  • Pituitary Neoplasms
  • Middle Aged
  • Microsurgery
  • Male