Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene.
Publication
, Journal Article
Burch, WM; Snyderman, R
Published in: Ann Intern Med
March 1982
A patient had progressive disseminated coccidioidomycosis and depressed cellular immunity to Coccidioides immitis. He developed a large nasal coccidioidal lesion that was unresponsive to conventional therapy. Application of dinitrochlorobenzene (DNCB) to the nasal lesion was temporally associated with resolution of the lesion and stabilization of the systemic disease. In addition, DNCB application was followed by signs of cellular immunity to C. immitis. These included development of delayed cutaneous hypersensitivity to coccidioidin, as well as lymphokine production and lymphoproliferative responses to coccidioidin. Similar forms of DNCB immunotherapy may prove useful in other patients with fungal disease and depressed cellular immunity.
Duke Scholars
Published In
Ann Intern Med
DOI
ISSN
0003-4819
Publication Date
March 1982
Volume
96
Issue
3
Start / End Page
329 / 331
Location
United States
Related Subject Headings
- Osteolysis
- Nitrobenzenes
- Male
- Immunotherapy
- Immunity, Cellular
- Humans
- General & Internal Medicine
- Dinitrochlorobenzene
- Dermatomycoses
- Coccidioidomycosis
Citation
APA
Chicago
ICMJE
MLA
NLM
Burch, W. M., & Snyderman, R. (1982). Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene. Ann Intern Med, 96(3), 329–331. https://doi.org/10.7326/0003-4819-96-3-329
Burch, W. M., and R. Snyderman. “Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene.” Ann Intern Med 96, no. 3 (March 1982): 329–31. https://doi.org/10.7326/0003-4819-96-3-329.
Burch WM, Snyderman R. Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene. Ann Intern Med. 1982 Mar;96(3):329–31.
Burch, W. M., and R. Snyderman. “Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene.” Ann Intern Med, vol. 96, no. 3, Mar. 1982, pp. 329–31. Pubmed, doi:10.7326/0003-4819-96-3-329.
Burch WM, Snyderman R. Induction of cellular immunity to Coccidioides immitis after sensitization with dinitrochlorobenzene. Ann Intern Med. 1982 Mar;96(3):329–331.
Published In
Ann Intern Med
DOI
ISSN
0003-4819
Publication Date
March 1982
Volume
96
Issue
3
Start / End Page
329 / 331
Location
United States
Related Subject Headings
- Osteolysis
- Nitrobenzenes
- Male
- Immunotherapy
- Immunity, Cellular
- Humans
- General & Internal Medicine
- Dinitrochlorobenzene
- Dermatomycoses
- Coccidioidomycosis