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The role restitution in pacing induced spiral wave acceleration.

Publication ,  Journal Article
Tranquillo, JV; Bursac, N
Published in: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
January 2006

Attempts to terminate monomorphic tachycardia by rapid pacing occasionally lead to acceleration of the tachycardia rate followed by fibrillation. Previous experimental studies have shown that rapid pacing can convert a single-wave functional reentry into a stable multi-wave reentry with accelerated rate, but only when the single spiral rate is significantly lower than the rate the tissue can sustain. In addition the acceleration was facilitated by broad and deep conduction velocity restitution. This study explores the mechanisms that modulate the potential for and degree of acceleration. Results demonstrate that ionic changes that affect CV restitution and increase core size of the functional reentry facilitate acceleration by wave multiplication. Understanding the mechanisms for reentry acceleration may yield new strategies that prevent the degeneration of tachycardia to fibrillation.

Duke Scholars

Published In

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

DOI

ISSN

1557-170X

Publication Date

January 2006

Volume

2006

Start / End Page

3919 / 3922

Related Subject Headings

  • Tachycardia
  • Models, Cardiovascular
  • Membrane Potentials
  • Humans
  • Heart Conduction System
  • Heart
  • Action Potentials
 

Citation

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Tranquillo, J. V., & Bursac, N. (2006). The role restitution in pacing induced spiral wave acceleration. Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2006, 3919–3922. https://doi.org/10.1109/iembs.2006.260035
Tranquillo, Joseph V., and Nenad Bursac. “The role restitution in pacing induced spiral wave acceleration.Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2006 (January 2006): 3919–22. https://doi.org/10.1109/iembs.2006.260035.
Tranquillo JV, Bursac N. The role restitution in pacing induced spiral wave acceleration. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2006 Jan;2006:3919–22.
Tranquillo, Joseph V., and Nenad Bursac. “The role restitution in pacing induced spiral wave acceleration.Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, vol. 2006, Jan. 2006, pp. 3919–22. Epmc, doi:10.1109/iembs.2006.260035.
Tranquillo JV, Bursac N. The role restitution in pacing induced spiral wave acceleration. Conference proceedings : . Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual Conference. 2006 Jan;2006:3919–3922.

Published In

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

DOI

ISSN

1557-170X

Publication Date

January 2006

Volume

2006

Start / End Page

3919 / 3922

Related Subject Headings

  • Tachycardia
  • Models, Cardiovascular
  • Membrane Potentials
  • Humans
  • Heart Conduction System
  • Heart
  • Action Potentials