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Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice.

Publication ,  Journal Article
Mork, L; Maatouk, DM; McMahon, JA; Guo, JJ; Zhang, P; McMahon, AP; Capel, B
Published in: Biol Reprod
February 2012

The embryonic origins of ovarian granulosa cells have been a subject of debate for decades. By tamoxifen-induced lineage tracing of Foxl2-expressing cells, we show that descendants of the bipotential supporting cell precursors in the early gonad contribute granulosa cells to a specific population of follicles in the medulla of the ovary that begin to grow immediately after birth. These precursor cells arise from the proliferative ovarian surface epithelium and enter mitotic arrest prior to upregulating Foxl2. Granulosa cells that populate the cortical primordial follicles activated in adult life derive from the surface epithelium perinatally, and enter mitotic arrest at that stage. Ingression from the surface epithelium dropped to undetectable levels by Postnatal Day 7, when most surviving oocytes were individually encapsulated by granulosa cells. These findings add complexity to the standard model of sex determination in which the Sertoli and granulosa cells of the adult testis and ovary directly stem from the supporting cell precursors of the bipotential gonad.

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Published In

Biol Reprod

DOI

EISSN

1529-7268

Publication Date

February 2012

Volume

86

Issue

2

Start / End Page

37

Location

United States

Related Subject Headings

  • Ovary
  • Ovarian Follicle
  • Obstetrics & Reproductive Medicine
  • Models, Animal
  • Mice, Transgenic
  • Mice
  • Granulosa Cells
  • Forkhead Transcription Factors
  • Forkhead Box Protein L2
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mork, L., Maatouk, D. M., McMahon, J. A., Guo, J. J., Zhang, P., McMahon, A. P., & Capel, B. (2012). Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. Biol Reprod, 86(2), 37. https://doi.org/10.1095/biolreprod.111.095208
Mork, Lindsey, Danielle M. Maatouk, Jill A. McMahon, Jin Jin Guo, Pumin Zhang, Andrew P. McMahon, and Blanche Capel. “Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice.Biol Reprod 86, no. 2 (February 2012): 37. https://doi.org/10.1095/biolreprod.111.095208.
Mork L, Maatouk DM, McMahon JA, Guo JJ, Zhang P, McMahon AP, et al. Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. Biol Reprod. 2012 Feb;86(2):37.
Mork, Lindsey, et al. “Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice.Biol Reprod, vol. 86, no. 2, Feb. 2012, p. 37. Pubmed, doi:10.1095/biolreprod.111.095208.
Mork L, Maatouk DM, McMahon JA, Guo JJ, Zhang P, McMahon AP, Capel B. Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. Biol Reprod. 2012 Feb;86(2):37.
Journal cover image

Published In

Biol Reprod

DOI

EISSN

1529-7268

Publication Date

February 2012

Volume

86

Issue

2

Start / End Page

37

Location

United States

Related Subject Headings

  • Ovary
  • Ovarian Follicle
  • Obstetrics & Reproductive Medicine
  • Models, Animal
  • Mice, Transgenic
  • Mice
  • Granulosa Cells
  • Forkhead Transcription Factors
  • Forkhead Box Protein L2
  • Female