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Bmp7 regulates germ cell proliferation in mouse fetal gonads.

Publication ,  Journal Article
Ross, A; Munger, S; Capel, B
Published in: Sex Dev
2007

Relatively little is known regarding the signals that regulate the proliferation and sex-specific development of germ cells during mammalian fetal gonad differentiation. Members of the bone morphogenetic protein (BMP) family have been identified as key regulators of germ cells in the Drosophila gonad. Here we show that in mice Bmp7 is expressed in gonads of both sexes and is required for germ cell proliferation during a narrow window of development between 10.5-11.5 days post coitum (dpc). The proliferation defect is more severe in male than in female embryos suggesting that there are sexually dimorphic compensatory pathways. BMP signaling appears to be an evolutionarily conserved pathway regulating embryonic germ cell proliferation in vertebrate and invertebrate species.

Duke Scholars

Published In

Sex Dev

DOI

EISSN

1661-5433

Publication Date

2007

Volume

1

Issue

2

Start / End Page

127 / 137

Location

Switzerland

Related Subject Headings

  • Transforming Growth Factor beta
  • Testis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ovary
  • Mice, Mutant Strains
  • Mice
  • Male
  • In Situ Hybridization
  • Immunohistochemistry
  • Hematoxylin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ross, A., Munger, S., & Capel, B. (2007). Bmp7 regulates germ cell proliferation in mouse fetal gonads. Sex Dev, 1(2), 127–137. https://doi.org/10.1159/000100034
Ross, A., S. Munger, and B. Capel. “Bmp7 regulates germ cell proliferation in mouse fetal gonads.Sex Dev 1, no. 2 (2007): 127–37. https://doi.org/10.1159/000100034.
Ross A, Munger S, Capel B. Bmp7 regulates germ cell proliferation in mouse fetal gonads. Sex Dev. 2007;1(2):127–37.
Ross, A., et al. “Bmp7 regulates germ cell proliferation in mouse fetal gonads.Sex Dev, vol. 1, no. 2, 2007, pp. 127–37. Pubmed, doi:10.1159/000100034.
Ross A, Munger S, Capel B. Bmp7 regulates germ cell proliferation in mouse fetal gonads. Sex Dev. 2007;1(2):127–137.
Journal cover image

Published In

Sex Dev

DOI

EISSN

1661-5433

Publication Date

2007

Volume

1

Issue

2

Start / End Page

127 / 137

Location

Switzerland

Related Subject Headings

  • Transforming Growth Factor beta
  • Testis
  • Reverse Transcriptase Polymerase Chain Reaction
  • Ovary
  • Mice, Mutant Strains
  • Mice
  • Male
  • In Situ Hybridization
  • Immunohistochemistry
  • Hematoxylin