T cell sensitivity and specificity - Kinetic proofreading revisited
Publication
, Journal Article
Chan, C; George, AJT; Stark, J
Published in: Discrete and Continuous Dynamical Systems Series B
January 1, 2003
T cells recognise foreign antigen presented by antigen presenting cells at extremely low concentrations, and are able to discriminate between different ligands with high specificity. McKeithan's kinetic proofreading model is often invoked to explain this sensitivity and specificity of the T cell. In this paper, we analyse the strengths and limitations of this model, and suggest that it does not seem adequate to explain the observed degree of T cell sensitivity, specificity and robustness.
Duke Scholars
Published In
Discrete and Continuous Dynamical Systems Series B
DOI
ISSN
1531-3492
Publication Date
January 1, 2003
Volume
3
Issue
3
Start / End Page
343 / 360
Related Subject Headings
- Applied Mathematics
- 4904 Pure mathematics
- 4901 Applied mathematics
- 0102 Applied Mathematics
- 0101 Pure Mathematics
Citation
APA
Chicago
ICMJE
MLA
NLM
Chan, C., George, A. J. T., & Stark, J. (2003). T cell sensitivity and specificity - Kinetic proofreading revisited. Discrete and Continuous Dynamical Systems Series B, 3(3), 343–360. https://doi.org/10.3934/dcdsb.2003.3.343
Chan, C., A. J. T. George, and J. Stark. “T cell sensitivity and specificity - Kinetic proofreading revisited.” Discrete and Continuous Dynamical Systems Series B 3, no. 3 (January 1, 2003): 343–60. https://doi.org/10.3934/dcdsb.2003.3.343.
Chan C, George AJT, Stark J. T cell sensitivity and specificity - Kinetic proofreading revisited. Discrete and Continuous Dynamical Systems Series B. 2003 Jan 1;3(3):343–60.
Chan, C., et al. “T cell sensitivity and specificity - Kinetic proofreading revisited.” Discrete and Continuous Dynamical Systems Series B, vol. 3, no. 3, Jan. 2003, pp. 343–60. Scopus, doi:10.3934/dcdsb.2003.3.343.
Chan C, George AJT, Stark J. T cell sensitivity and specificity - Kinetic proofreading revisited. Discrete and Continuous Dynamical Systems Series B. 2003 Jan 1;3(3):343–360.
Published In
Discrete and Continuous Dynamical Systems Series B
DOI
ISSN
1531-3492
Publication Date
January 1, 2003
Volume
3
Issue
3
Start / End Page
343 / 360
Related Subject Headings
- Applied Mathematics
- 4904 Pure mathematics
- 4901 Applied mathematics
- 0102 Applied Mathematics
- 0101 Pure Mathematics