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Prevention of GVHD without losing GVL effect: windows of opportunity.

Publication ,  Journal Article
Zhang, P; Chen, BJ; Chao, NJ
Published in: Immunol Res
April 2011

Allogeneic hematopoietic cell transplantation has developed into a most successful form of immunotherapy for hematologic malignancies in the past 50 years. However, its effectiveness and wider applications have been greatly limited by the development of graft-versus-host disease (GVHD), a potentially lethal side effect associated with this procedure. Since the main effectors for both graft-versus-leukemia (GVL) effect and GVHD are T lymphocytes and these two processes share many similar pathways, it has not been easy to separate GVL from GVHD. Because the clinically used pan immunosuppressive therapy for GVHD prevention also results in decreased GVL effect, the success of allogeneic hematopoietic cell transplantation relies on a small and unpredictable therapeutic window at the present time. This review discusses how we may widen this therapeutic window so that we can reliably prevent GVHD without losing GVL effect.

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Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

49 / 55

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • T-Lymphocytes
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Hematologic Neoplasms
  • Graft vs Leukemia Effect
  • Graft vs Host Disease
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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Zhang, P., Chen, B. J., & Chao, N. J. (2011). Prevention of GVHD without losing GVL effect: windows of opportunity. Immunol Res, 49(1–3), 49–55. https://doi.org/10.1007/s12026-010-8193-7
Zhang, Ping, Benny J. Chen, and Nelson J. Chao. “Prevention of GVHD without losing GVL effect: windows of opportunity.Immunol Res 49, no. 1–3 (April 2011): 49–55. https://doi.org/10.1007/s12026-010-8193-7.
Zhang P, Chen BJ, Chao NJ. Prevention of GVHD without losing GVL effect: windows of opportunity. Immunol Res. 2011 Apr;49(1–3):49–55.
Zhang, Ping, et al. “Prevention of GVHD without losing GVL effect: windows of opportunity.Immunol Res, vol. 49, no. 1–3, Apr. 2011, pp. 49–55. Pubmed, doi:10.1007/s12026-010-8193-7.
Zhang P, Chen BJ, Chao NJ. Prevention of GVHD without losing GVL effect: windows of opportunity. Immunol Res. 2011 Apr;49(1–3):49–55.
Journal cover image

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

49 / 55

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • T-Lymphocytes
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Hematologic Neoplasms
  • Graft vs Leukemia Effect
  • Graft vs Host Disease
  • 3204 Immunology
  • 1107 Immunology