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Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.

Publication ,  Journal Article
Meadows, SK; Dressman, HK; Muramoto, GG; Himburg, H; Salter, A; Wei, Z; Ginsburg, GS; Chao, NJ; Nevins, JR; Chute, JP
Published in: PLoS One
April 2, 2008

BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the impact of several variables on the PB gene expression profile of an environmental exposure, ionizing radiation, and to determine the specificity of the PB signature of radiation versus other genotoxic stresses. Neither genotype differences nor the time of PB sampling caused any lessening of the accuracy of PB signatures to predict radiation exposure, but sex difference did influence the accuracy of the prediction of radiation exposure at the lowest level (50 cGy). A PB signature of sepsis was also generated and both the PB signature of radiation and the PB signature of sepsis were found to be 100% specific at distinguishing irradiated from septic animals. We also identified human PB signatures of radiation exposure and chemotherapy treatment which distinguished irradiated patients and chemotherapy-treated individuals within a heterogeneous population with accuracies of 90% and 81%, respectively. CONCLUSIONS: We conclude that PB gene expression profiles can be identified in mice and humans that are accurate in predicting medical conditions, are specific to each condition and remain highly accurate over time.

Duke Scholars

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

April 2, 2008

Volume

3

Issue

4

Start / End Page

e1912

Location

United States

Related Subject Headings

  • Reproducibility of Results
  • Radiation, Ionizing
  • Radiation Tolerance
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lipopolysaccharides
  • Humans
  • General Science & Technology
 

Citation

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Meadows, S. K., Dressman, H. K., Muramoto, G. G., Himburg, H., Salter, A., Wei, Z., … Chute, J. P. (2008). Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One, 3(4), e1912. https://doi.org/10.1371/journal.pone.0001912
Meadows, Sarah K., Holly K. Dressman, Garrett G. Muramoto, Heather Himburg, Alice Salter, ZhengZheng Wei, Geoffrey S. Ginsburg, Nelson J. Chao, Joseph R. Nevins, and John P. Chute. “Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.PLoS One 3, no. 4 (April 2, 2008): e1912. https://doi.org/10.1371/journal.pone.0001912.
Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, et al. Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One. 2008 Apr 2;3(4):e1912.
Meadows, Sarah K., et al. “Gene expression signatures of radiation response are specific, durable and accurate in mice and humans.PLoS One, vol. 3, no. 4, Apr. 2008, p. e1912. Pubmed, doi:10.1371/journal.pone.0001912.
Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, Ginsburg GS, Chao NJ, Nevins JR, Chute JP. Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One. 2008 Apr 2;3(4):e1912.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

April 2, 2008

Volume

3

Issue

4

Start / End Page

e1912

Location

United States

Related Subject Headings

  • Reproducibility of Results
  • Radiation, Ionizing
  • Radiation Tolerance
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lipopolysaccharides
  • Humans
  • General Science & Technology