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CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice.

Publication ,  Journal Article
Zhang, J; Barefoot, BE; Mo, W; Deoliveira, D; Son, J; Cui, X; Ramsburg, E; Chen, BJ
Published in: Blood
June 28, 2012

A major challenge in allogeneic hematopoietic cell transplantation is how to transfer T-cell immunity without causing graft-versus-host disease (GVHD). Effector memory T cells (CD62L(-)) are a cell subset that can potentially address this challenge because they do not induce GVHD. Here, we investigated how CD62L(-) T cells contributed to phenotypic and functional T-cell reconstitution after transplantation. On transfer into allogeneic recipients, CD62L(-) T cells were activated and expressed multiple cytokines and cytotoxic molecules. CD62L(-) T cells were able to deplete host radioresistant T cells and facilitate hematopoietic engraftment, resulting in enhanced de novo T-cell regeneration. Enhanced functional immune reconstitution was demonstrated in CD62L(-) T-cell recipients using a tumor and an influenza virus challenge model. Even though CD62L(-) T cells are able to respond to alloantigens and deplete host radioresistant immune cells in GVHD recipients, alloreactive CD62L(-) T cells lost the reactivity over time and were eventually tolerant to alloantigens as a result of prolonged antigen exposure, suggesting a mechanism by which CD62L(-) T cells were able to eliminate host resistance without causing GVHD. These data further highlight the unique characteristics of CD62L(-) T cells and their potential applications in clinical hematopoietic cell transplantation.

Duke Scholars

Published In

Blood

DOI

EISSN

1528-0020

Publication Date

June 28, 2012

Volume

119

Issue

26

Start / End Page

6344 / 6353

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Tolerance
  • T-Lymphocytes
  • Mice, SCID
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Male
  • L-Selectin
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, J., Barefoot, B. E., Mo, W., Deoliveira, D., Son, J., Cui, X., … Chen, B. J. (2012). CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice. Blood, 119(26), 6344–6353. https://doi.org/10.1182/blood-2011-03-342055
Zhang, Jifeng, Brice E. Barefoot, Wenjian Mo, Divino Deoliveira, Jessica Son, Xiuyu Cui, Elizabeth Ramsburg, and Benny J. Chen. “CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice.Blood 119, no. 26 (June 28, 2012): 6344–53. https://doi.org/10.1182/blood-2011-03-342055.
Zhang J, Barefoot BE, Mo W, Deoliveira D, Son J, Cui X, et al. CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice. Blood. 2012 Jun 28;119(26):6344–53.
Zhang, Jifeng, et al. “CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice.Blood, vol. 119, no. 26, June 2012, pp. 6344–53. Pubmed, doi:10.1182/blood-2011-03-342055.
Zhang J, Barefoot BE, Mo W, Deoliveira D, Son J, Cui X, Ramsburg E, Chen BJ. CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice. Blood. 2012 Jun 28;119(26):6344–6353.

Published In

Blood

DOI

EISSN

1528-0020

Publication Date

June 28, 2012

Volume

119

Issue

26

Start / End Page

6344 / 6353

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Tolerance
  • T-Lymphocytes
  • Mice, SCID
  • Mice, Inbred C57BL
  • Mice, Inbred BALB C
  • Mice
  • Male
  • L-Selectin
  • Immunology