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Allogeneic memory T cell response.

Publication ,  Journal Article
Chen, BJ
Published in: Biol Blood Marrow Transplant
January 2008

Recent data have revealed marked differences in alloresponses mediated by memory T cells during GVH and host-versus-graft (HVG) reactions (summarized in Table 1). Even though the mechanisms are not completely understood, it is clear that all memory T cells including nonallospecific, crossreactive, and allospecific memory T cells have decreased ability to induce GVHD. Selection of memory T cells or removal of naïve T cells will not only prevent GVHD, but could also enhance immune reconstitution, facilitate engraftment, and have the potential to enhance antitumor effects. A clinical trial has been planned. Successful translation of this approach in the clinic will improve the safety, enhance the effectiveness, and broaden the scope of allogeneic hematopoietic stem cell transplantation.

Duke Scholars

Published In

Biol Blood Marrow Transplant

EISSN

1523-6536

Publication Date

January 2008

Volume

14

Issue

1 Suppl 1

Start / End Page

20 / 22

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Mice
  • Immunology
  • Immunologic Memory
  • Humans
  • Host vs Graft Reaction
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Reaction
  • Graft vs Host Disease
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, B. J. (2008). Allogeneic memory T cell response. Biol Blood Marrow Transplant, 14(1 Suppl 1), 20–22.
Chen, Benny J. “Allogeneic memory T cell response.Biol Blood Marrow Transplant 14, no. 1 Suppl 1 (January 2008): 20–22.
Chen BJ. Allogeneic memory T cell response. Biol Blood Marrow Transplant. 2008 Jan;14(1 Suppl 1):20–2.
Chen, Benny J. “Allogeneic memory T cell response.Biol Blood Marrow Transplant, vol. 14, no. 1 Suppl 1, Jan. 2008, pp. 20–22.
Chen BJ. Allogeneic memory T cell response. Biol Blood Marrow Transplant. 2008 Jan;14(1 Suppl 1):20–22.
Journal cover image

Published In

Biol Blood Marrow Transplant

EISSN

1523-6536

Publication Date

January 2008

Volume

14

Issue

1 Suppl 1

Start / End Page

20 / 22

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Mice
  • Immunology
  • Immunologic Memory
  • Humans
  • Host vs Graft Reaction
  • Hematopoietic Stem Cell Transplantation
  • Graft vs Host Reaction
  • Graft vs Host Disease
  • Animals