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Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents.

Publication ,  Journal Article
MacEwan, SR; Chilkoti, A
Published in: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
January 2013

Targeted delivery of cancer therapeutics and imaging agents aims to enhance the accumulation of these molecules in a solid tumor while avoiding uptake in healthy tissues. Tumor-specific accumulation has been pursued with passive targeting by the enhanced permeability and retention effect, as well as with active targeting strategies. Active targeting is achieved by functionalization of carriers to allow specific interactions between the carrier and the tumor environment. Functionalization of carriers with ligands that specifically interact with overexpressed receptors on cancer cells represents a classic approach to active tumor targeting. Cell-penetrating peptides (CPPs) provide a non-specific and receptor-independent mechanism to enhance cellular uptake that offers an exciting alternative to traditional active targeting approaches. While the non-specificity of CPP-mediated internalization has the intriguing potential to make this approach applicable to a wide range of tumor types, their promiscuity is, however, a significant barrier to their clinical utility for systemically administered applications. Many approaches have been investigated to selectively turn on the function of systemically delivered CPP-functionalized carriers specifically in tumors to achieve targeted delivery of cancer therapeutics and imaging agents.

Duke Scholars

Published In

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

DOI

EISSN

1939-0041

ISSN

1939-5116

Publication Date

January 2013

Volume

5

Issue

1

Start / End Page

31 / 48

Related Subject Headings

  • Neoplasms
  • Nanoscience & Nanotechnology
  • Micelles
  • Mice
  • Humans
  • Drug Carriers
  • Cell-Penetrating Peptides
  • Cell Line, Tumor
  • Animals
  • 4018 Nanotechnology
 

Citation

APA
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ICMJE
MLA
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MacEwan, S. R., & Chilkoti, A. (2013). Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, 5(1), 31–48. https://doi.org/10.1002/wnan.1197
MacEwan, Sarah R., and Ashutosh Chilkoti. “Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents.Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 5, no. 1 (January 2013): 31–48. https://doi.org/10.1002/wnan.1197.
MacEwan SR, Chilkoti A. Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents. Wiley interdisciplinary reviews Nanomedicine and nanobiotechnology. 2013 Jan;5(1):31–48.
MacEwan, Sarah R., and Ashutosh Chilkoti. “Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents.Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, vol. 5, no. 1, Jan. 2013, pp. 31–48. Epmc, doi:10.1002/wnan.1197.
MacEwan SR, Chilkoti A. Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents. Wiley interdisciplinary reviews Nanomedicine and nanobiotechnology. 2013 Jan;5(1):31–48.
Journal cover image

Published In

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

DOI

EISSN

1939-0041

ISSN

1939-5116

Publication Date

January 2013

Volume

5

Issue

1

Start / End Page

31 / 48

Related Subject Headings

  • Neoplasms
  • Nanoscience & Nanotechnology
  • Micelles
  • Mice
  • Humans
  • Drug Carriers
  • Cell-Penetrating Peptides
  • Cell Line, Tumor
  • Animals
  • 4018 Nanotechnology