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Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.

Publication ,  Journal Article
MacEwan, SR; Callahan, DJ; Chilkoti, A
Published in: Nanomedicine (London, England)
July 2010

Nanoparticles and macromolecular carriers have been widely used to increase the efficacy of chemotherapeutics, largely through passive accumulation provided by the enhanced permeability and retention effect. Stimulus-responsive peptide and polymer vehicles can further enhance the efficacy of antitumor therapeutics compared with the administration of free drug by three mechanisms: increasing the overall accumulation within solid tumors; providing a homogeneous spatial distribution in tumor tissues; and increasing the intracellular localization of anticancer therapeutics. This article highlights recent developments in 'smart' - stimulus-responsive - peptide, polymer and lipid drug carriers designed to enhance the localization and efficacy of therapeutic payloads as compared with free drug.

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Published In

Nanomedicine (London, England)

DOI

EISSN

1748-6963

ISSN

1743-5889

Publication Date

July 2010

Volume

5

Issue

5

Start / End Page

793 / 806

Related Subject Headings

  • Polymers
  • Peptides
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Humans
  • Drug Carriers
  • Antineoplastic Agents
  • Animals
  • 4018 Nanotechnology
 

Citation

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ICMJE
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MacEwan, S. R., Callahan, D. J., & Chilkoti, A. (2010). Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery. Nanomedicine (London, England), 5(5), 793–806. https://doi.org/10.2217/nnm.10.50
MacEwan, Sarah R., Daniel J. Callahan, and Ashutosh Chilkoti. “Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.Nanomedicine (London, England) 5, no. 5 (July 2010): 793–806. https://doi.org/10.2217/nnm.10.50.
MacEwan SR, Callahan DJ, Chilkoti A. Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery. Nanomedicine (London, England). 2010 Jul;5(5):793–806.
MacEwan, Sarah R., et al. “Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.Nanomedicine (London, England), vol. 5, no. 5, July 2010, pp. 793–806. Epmc, doi:10.2217/nnm.10.50.
MacEwan SR, Callahan DJ, Chilkoti A. Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery. Nanomedicine (London, England). 2010 Jul;5(5):793–806.
Journal cover image

Published In

Nanomedicine (London, England)

DOI

EISSN

1748-6963

ISSN

1743-5889

Publication Date

July 2010

Volume

5

Issue

5

Start / End Page

793 / 806

Related Subject Headings

  • Polymers
  • Peptides
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Humans
  • Drug Carriers
  • Antineoplastic Agents
  • Animals
  • 4018 Nanotechnology