Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel

Minireview: Nuclear receptors, hematopoiesis, and stem cells.

Publication ,  Journal Article
Chute, JP; Ross, JR; McDonnell, DP
Published in: Mol Endocrinol
January 2010

Nuclear receptors (NRs) regulate a panoply of biological processes, including the function and development of cells within the hematopoietic and immune system, such as erythrocytes, monocytes, and lymphocytes. Significantly less is known regarding the function of NRs in regulating the fate of hematopoietic stem cells (HSCs), the self-renewing, pluripotent cells that give rise to the entirety of the blood and immune systems throughout the lifetime of an individual. Several recent studies suggest, either directly or indirectly, a role for members of the NR family in regulating the differentiation and self-renewal of HSCs, embryonic stem cells, and induced pluripotent stem cells. Herein, we review in detail the function of specific NRs in controlling HSC and other stem cell fate and propose a framework through which these observations can be translated into therapeutic amplification of HSCs for clinical purposes.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Mol Endocrinol

DOI

EISSN

1944-9917

Publication Date

January 2010

Volume

24

Issue

1

Start / End Page

1 / 10

Location

United States

Related Subject Headings

  • Receptors, Cytoplasmic and Nuclear
  • Male
  • Induced Pluripotent Stem Cells
  • Humans
  • Hematopoietic Stem Cells
  • Hematopoiesis
  • Female
  • Endocrinology & Metabolism
  • Embryonic Stem Cells
  • Cell Differentiation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chute, J. P., Ross, J. R., & McDonnell, D. P. (2010). Minireview: Nuclear receptors, hematopoiesis, and stem cells. Mol Endocrinol, 24(1), 1–10. https://doi.org/10.1210/me.2009-0332
Chute, John P., Joel R. Ross, and Donald P. McDonnell. “Minireview: Nuclear receptors, hematopoiesis, and stem cells.Mol Endocrinol 24, no. 1 (January 2010): 1–10. https://doi.org/10.1210/me.2009-0332.
Chute JP, Ross JR, McDonnell DP. Minireview: Nuclear receptors, hematopoiesis, and stem cells. Mol Endocrinol. 2010 Jan;24(1):1–10.
Chute, John P., et al. “Minireview: Nuclear receptors, hematopoiesis, and stem cells.Mol Endocrinol, vol. 24, no. 1, Jan. 2010, pp. 1–10. Pubmed, doi:10.1210/me.2009-0332.
Chute JP, Ross JR, McDonnell DP. Minireview: Nuclear receptors, hematopoiesis, and stem cells. Mol Endocrinol. 2010 Jan;24(1):1–10.

Published In

Mol Endocrinol

DOI

EISSN

1944-9917

Publication Date

January 2010

Volume

24

Issue

1

Start / End Page

1 / 10

Location

United States

Related Subject Headings

  • Receptors, Cytoplasmic and Nuclear
  • Male
  • Induced Pluripotent Stem Cells
  • Humans
  • Hematopoietic Stem Cells
  • Hematopoiesis
  • Female
  • Endocrinology & Metabolism
  • Embryonic Stem Cells
  • Cell Differentiation