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New insights into angiotensin receptor actions: from blood pressure to aging.

Publication ,  Journal Article
Stegbauer, J; Coffman, TM
Published in: Curr Opin Nephrol Hypertens
January 2011

PURPOSE OF REVIEW: The renin-angiotensin system (RAS) is critical for cardiovascular control, impacting normal physiology and disease pathogenesis. Although several biologically active peptides are generated by this system, its major actions are mediated by angiotensin II acting through its type 1 (AT1) and type 2 (AT2) receptors. Along with their effects to influence blood pressure and hemodynamics, recent studies have provided evidence that angiotensin receptors influence a range of processes independent from hemodynamic effects. RECENT FINDINGS: This review is focused on new molecular mechanisms underlying actions of AT1 receptors to influence vasoconstriction, inflammation, immune responses, and longevity. Moreover, we also highlight new advances in understanding functions of the AT2 receptor in end-organ damage, emphasizing the AT2 receptor as a potential therapeutic target in cardiovascular diseases. SUMMARY: Here we review recent advances in understanding the role of angiotensin receptors in normal physiology and disease states, focusing on their properties that may contribute to blood pressure regulation, end-organ damage, autoimmune disease and longevity.

Duke Scholars

Published In

Curr Opin Nephrol Hypertens

DOI

EISSN

1473-6543

Publication Date

January 2011

Volume

20

Issue

1

Start / End Page

84 / 88

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Signal Transduction
  • Receptor, Angiotensin, Type 2
  • Receptor, Angiotensin, Type 1
  • Humans
  • Homeostasis
  • Blood Pressure
  • Autoimmune Diseases
  • Animals
  • Aging
 

Citation

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Stegbauer, J., & Coffman, T. M. (2011). New insights into angiotensin receptor actions: from blood pressure to aging. Curr Opin Nephrol Hypertens, 20(1), 84–88. https://doi.org/10.1097/MNH.0b013e3283414d40
Stegbauer, Johannes, and Thomas M. Coffman. “New insights into angiotensin receptor actions: from blood pressure to aging.Curr Opin Nephrol Hypertens 20, no. 1 (January 2011): 84–88. https://doi.org/10.1097/MNH.0b013e3283414d40.
Stegbauer J, Coffman TM. New insights into angiotensin receptor actions: from blood pressure to aging. Curr Opin Nephrol Hypertens. 2011 Jan;20(1):84–8.
Stegbauer, Johannes, and Thomas M. Coffman. “New insights into angiotensin receptor actions: from blood pressure to aging.Curr Opin Nephrol Hypertens, vol. 20, no. 1, Jan. 2011, pp. 84–88. Pubmed, doi:10.1097/MNH.0b013e3283414d40.
Stegbauer J, Coffman TM. New insights into angiotensin receptor actions: from blood pressure to aging. Curr Opin Nephrol Hypertens. 2011 Jan;20(1):84–88.

Published In

Curr Opin Nephrol Hypertens

DOI

EISSN

1473-6543

Publication Date

January 2011

Volume

20

Issue

1

Start / End Page

84 / 88

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Signal Transduction
  • Receptor, Angiotensin, Type 2
  • Receptor, Angiotensin, Type 1
  • Humans
  • Homeostasis
  • Blood Pressure
  • Autoimmune Diseases
  • Animals
  • Aging