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Familial influence and childhood trauma in female alcoholism.

Publication ,  Journal Article
Magnusson, Å; Lundholm, C; Göransson, M; Copeland, W; Heilig, M; Pedersen, NL
Published in: Psychol Med
February 2012

BACKGROUND: To assess the role of genetic and environmental factors in female alcoholism using a large population-based twin sample, taking into account possible differences between early and late onset disease subtype. METHOD: Twins aged 20-47 years from the Swedish Twin Registry (n=24 119) answered questions to establish lifetime alcohol use disorders. Subjects with alcoholism were classified for subtype. Structural equation modeling was used to quantify the proportion of phenotypic variance due to genetic and environmental factors and test whether heritability in women differed from that in men. The association between childhood trauma and alcoholism was then examined in females, controlling for background familial factors. RESULTS: Lifetime prevalence of alcohol dependence was 4.9% in women and 8.6% in men. Overall, heritability for alcohol dependence was 55%, and did not differ significantly between men and women, although women had a significantly greater heritability for late onset (type I). Childhood physical trauma and sexual abuse had a stronger association with early onset compared to late onset alcoholism [odds ratio (OR) 2.54, 95% confidence interval (CI) 1.53-3.88 and OR 2.29, 95% CI 1.38-3.79 respectively]. Co-twin analysis indicated that familial factors largely accounted for the influence of physical trauma whereas the association with childhood sexual abuse reflected both familial and specific effects. CONCLUSIONS: Heritability of alcoholism in women is similar to that in men. Early onset alcoholism is strongly association with childhood trauma, which seems to be both a marker of familial background factors and a specific individual risk factor per se.

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Published In

Psychol Med

DOI

EISSN

1469-8978

Publication Date

February 2012

Volume

42

Issue

2

Start / End Page

381 / 389

Location

England

Related Subject Headings

  • Young Adult
  • Sweden
  • Sex Factors
  • Risk Factors
  • Registries
  • Psychiatry
  • Middle Aged
  • Male
  • Humans
  • Genetic Predisposition to Disease
 

Citation

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Magnusson, Å., Lundholm, C., Göransson, M., Copeland, W., Heilig, M., & Pedersen, N. L. (2012). Familial influence and childhood trauma in female alcoholism. Psychol Med, 42(2), 381–389. https://doi.org/10.1017/S0033291711001310
Magnusson, Å., C. Lundholm, M. Göransson, W. Copeland, M. Heilig, and N. L. Pedersen. “Familial influence and childhood trauma in female alcoholism.Psychol Med 42, no. 2 (February 2012): 381–89. https://doi.org/10.1017/S0033291711001310.
Magnusson Å, Lundholm C, Göransson M, Copeland W, Heilig M, Pedersen NL. Familial influence and childhood trauma in female alcoholism. Psychol Med. 2012 Feb;42(2):381–9.
Magnusson, Å., et al. “Familial influence and childhood trauma in female alcoholism.Psychol Med, vol. 42, no. 2, Feb. 2012, pp. 381–89. Pubmed, doi:10.1017/S0033291711001310.
Magnusson Å, Lundholm C, Göransson M, Copeland W, Heilig M, Pedersen NL. Familial influence and childhood trauma in female alcoholism. Psychol Med. 2012 Feb;42(2):381–389.
Journal cover image

Published In

Psychol Med

DOI

EISSN

1469-8978

Publication Date

February 2012

Volume

42

Issue

2

Start / End Page

381 / 389

Location

England

Related Subject Headings

  • Young Adult
  • Sweden
  • Sex Factors
  • Risk Factors
  • Registries
  • Psychiatry
  • Middle Aged
  • Male
  • Humans
  • Genetic Predisposition to Disease