Scholars@Duke publication: Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression.

Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression.

Publication , Journal Article

de Barreda, EG; Dawson, HN; Vitek, MP; Avila, J

Published in: FEBS Lett

June 3, 2010

Although tau is mainly located in the cell cytoplasm, mostly bound to tubulin, it may also be found in the nucleus of neurons. Hence, we tested whether tau might play a role in regulating the expression of certain genes by comparing gene expression in mice containing or lacking the tau protein. Our results identified a significant difference in the expression of the smarce1 gene, which codes for the BAF-57 protein, a protein involved in the repression of neuron specific genes. These data suggest a role for tau in neuron maturation.

Duke Scholars

Author Michael P. Vitek Neurology, Behavioral Neurology

Published In

FEBS Lett

DOI

10.1016/j.febslet.2010.03.032

EISSN

1873-3468

Publication Date

June 3, 2010

Volume

584

Issue

Start / End Page

2265 / 2270

Location

England

Related Subject Headings

tau Proteins
Up-Regulation
Tubulin
Neurons
Mice, Knockout
Mice
Gene Expression
Cytoskeletal Proteins
Cytoplasm
Chromosomal Proteins, Non-Histone

Citation

APA

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MLA

NLM

de Barreda, E. G., Dawson, H. N., Vitek, M. P., & Avila, J. (2010). Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. FEBS Lett, 584(11), 2265–2270. https://doi.org/10.1016/j.febslet.2010.03.032

Barreda, Elena Gómez de, Hana N. Dawson, Michel P. Vitek, and Jesús Avila. “Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression.” FEBS Lett 584, no. 11 (June 3, 2010): 2265–70. https://doi.org/10.1016/j.febslet.2010.03.032.

de Barreda EG, Dawson HN, Vitek MP, Avila J. Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. FEBS Lett. 2010 Jun 3;584(11):2265–70.

de Barreda, Elena Gómez, et al. “Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression.” FEBS Lett, vol. 584, no. 11, June 2010, pp. 2265–70. Pubmed, doi:10.1016/j.febslet.2010.03.032.

de Barreda EG, Dawson HN, Vitek MP, Avila J. Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. FEBS Lett. 2010 Jun 3;584(11):2265–2270.