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Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases.

Publication ,  Journal Article
Rohowsky-Kochan, C; Eiman, D; Troiano, R; Bansil, S; Oleske, J; Denny, T; Cook, SD
Published in: J Neuroimmunol
July 1990

Decreased numbers of CD4+CD45R+ suppressor-inducer T cells have been reported in patients with a variety of autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis but not in patients with other neurological diseases. We now report our findings using murine monoclonal antibodies and two-color flow cytometric analysis on CD4+CD45R+ T cells in 22 patients with chronic progressive multiple sclerosis, 23 patients with other neurological diseases and 42 normal, healthy controls. Suppressor-inducer T cells were significantly reduced (p less than 0.001) in both patients with multiple sclerosis and other neurological diseases as compared to controls. Both patient populations had elevated helper T cell subset ratios. Thus, our data suggests that decreases in suppressor-inducer T cells may represent a common immunological defect among autoimmune and presumably non-autoimmune neurological disorders.

Duke Scholars

Published In

J Neuroimmunol

DOI

ISSN

0165-5728

Publication Date

July 1990

Volume

28

Issue

2

Start / End Page

161 / 166

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes
  • Reference Values
  • Neurology & Neurosurgery
  • Nervous System Diseases
  • Multiple Sclerosis
  • Middle Aged
  • Leukocyte Count
  • Leukocyte Common Antigens
  • Humans
 

Citation

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Rohowsky-Kochan, C., Eiman, D., Troiano, R., Bansil, S., Oleske, J., Denny, T., & Cook, S. D. (1990). Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases. J Neuroimmunol, 28(2), 161–166. https://doi.org/10.1016/0165-5728(90)90030-q
Rohowsky-Kochan, C., D. Eiman, R. Troiano, S. Bansil, J. Oleske, T. Denny, and S. D. Cook. “Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases.J Neuroimmunol 28, no. 2 (July 1990): 161–66. https://doi.org/10.1016/0165-5728(90)90030-q.
Rohowsky-Kochan C, Eiman D, Troiano R, Bansil S, Oleske J, Denny T, et al. Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases. J Neuroimmunol. 1990 Jul;28(2):161–6.
Rohowsky-Kochan, C., et al. “Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases.J Neuroimmunol, vol. 28, no. 2, July 1990, pp. 161–66. Pubmed, doi:10.1016/0165-5728(90)90030-q.
Rohowsky-Kochan C, Eiman D, Troiano R, Bansil S, Oleske J, Denny T, Cook SD. Decreased suppressor-inducer T lymphocytes in multiple sclerosis and other neurological diseases. J Neuroimmunol. 1990 Jul;28(2):161–166.
Journal cover image

Published In

J Neuroimmunol

DOI

ISSN

0165-5728

Publication Date

July 1990

Volume

28

Issue

2

Start / End Page

161 / 166

Location

Netherlands

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes
  • Reference Values
  • Neurology & Neurosurgery
  • Nervous System Diseases
  • Multiple Sclerosis
  • Middle Aged
  • Leukocyte Count
  • Leukocyte Common Antigens
  • Humans