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A 400 MHz hyperthermia system using rotating spiral antennas for uniform treatment of large superficial and sub-surface tumors

Publication ,  Journal Article
Arabe, OA; Maccarini, PF; Jones, EL; Hanna, G; Samulski, TV; Dewhirst, MW; Thrall, DE; Stauffer, PR
Published in: IEEE MTT-S International Microwave Symposium Digest
October 2, 2007

Numerous studies have shown that hyperthermia can significantly increase the tumor-killing effects of radiation therapy and/or chemotherapy. Superficial tumors are usually treated with waveguide-based systems operating at 915 MHz which do not heat evenly or deeply enough for typical disease that spreads below and across the skin surface. A 400MHz system that has been shown capable of treating somewhat larger and deeper volumes in previous animal and human clinical trials is investigated in this effort with the intent to further improve the technology. Real-time temperature, oxygen, and power reflection coefficient measurements are added for accurate control and deposition of the prescribed thermal dose while also assessing physiological response of the treated area. The hearing performance of three spiral antenna applicators is evaluated in two ways. First the power deposition pattern is simulated with Ansoft HFSS for a single stationary microstrip spiral applicator radiating into muscle tissue. Next the power deposition averaged over one cycle of rotation is simulated with Ansoft HFSS for a single asymmetrically rotated spiral, and for larger heating patterns an asymmetrically rotated two antenna spiral array. To verify the simulations, the power deposition pattern of the largest dual spiral scanning applicator was evaluated in a muscle equivalent tissue phantom using infrared imaging of a 'splitphantom' load and the results compared to the HFSS simulated patterns. The data show that these spiral antennas heat uniformly above 50% of the maximum heating rate just beyond the perimeter of the scanning or fixed spiral structure, producing for the largest dual spiral a 17cm diameter region at a depth of 3cm. The results of a previous human clinical trial using these spiral applicators is presented along with our plans to optimize the applicator in terms of real time control and extent of hearing based on new HFSS modeling and thermal analysis tools. © 2007 IEEE.

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Published In

IEEE MTT-S International Microwave Symposium Digest

DOI

ISSN

0149-645X

Publication Date

October 2, 2007

Start / End Page

1333 / 1336
 

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Arabe, O. A., Maccarini, P. F., Jones, E. L., Hanna, G., Samulski, T. V., Dewhirst, M. W., … Stauffer, P. R. (2007). A 400 MHz hyperthermia system using rotating spiral antennas for uniform treatment of large superficial and sub-surface tumors. IEEE MTT-S International Microwave Symposium Digest, 1333–1336. https://doi.org/10.1109/MWSYM.2007.380458
Arabe, O. A., P. F. Maccarini, E. L. Jones, G. Hanna, T. V. Samulski, M. W. Dewhirst, D. E. Thrall, and P. R. Stauffer. “A 400 MHz hyperthermia system using rotating spiral antennas for uniform treatment of large superficial and sub-surface tumors.” IEEE MTT-S International Microwave Symposium Digest, October 2, 2007, 1333–36. https://doi.org/10.1109/MWSYM.2007.380458.
Arabe OA, Maccarini PF, Jones EL, Hanna G, Samulski TV, Dewhirst MW, et al. A 400 MHz hyperthermia system using rotating spiral antennas for uniform treatment of large superficial and sub-surface tumors. IEEE MTT-S International Microwave Symposium Digest. 2007 Oct 2;1333–6.
Arabe, O. A., et al. “A 400 MHz hyperthermia system using rotating spiral antennas for uniform treatment of large superficial and sub-surface tumors.” IEEE MTT-S International Microwave Symposium Digest, Oct. 2007, pp. 1333–36. Scopus, doi:10.1109/MWSYM.2007.380458.
Arabe OA, Maccarini PF, Jones EL, Hanna G, Samulski TV, Dewhirst MW, Thrall DE, Stauffer PR. A 400 MHz hyperthermia system using rotating spiral antennas for uniform treatment of large superficial and sub-surface tumors. IEEE MTT-S International Microwave Symposium Digest. 2007 Oct 2;1333–1336.

Published In

IEEE MTT-S International Microwave Symposium Digest

DOI

ISSN

0149-645X

Publication Date

October 2, 2007

Start / End Page

1333 / 1336