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Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus.

Publication ,  Journal Article
Wassenberg, DM; Swails, EE; Di Giulio, RT
Published in: Marine environmental research
September 2002

The goal of this study was to assess the interactive effects of a polynuclear aromatic hydrocarbon (PAH), benzo(a)pyrene (BaP), and a co-planar halogenated aromatic hydrocarbon (HAH), 3,3'4,4'5-pentachlorobiphenyl (PCB 126) on ethoxyresorufin-O-deethylase (EROD) activity and occurrence of deformities in Fundulus heteroclitus. While each compound administered alone elicited dose-dependent increases in EROD activity, the combined treatment of these two compounds generally did not elicit an additive EROD response. There was a significant correlation between deformity occurrence and EROD induction in embryos dosed with PCB alone but not for embryos dosed with BaP alone, or a combination of BaP and PCB 126.

Duke Scholars

Published In

Marine environmental research

DOI

EISSN

1879-0291

ISSN

0141-1136

Publication Date

September 2002

Volume

54

Issue

3-5

Start / End Page

279 / 283

Related Subject Headings

  • Polychlorinated Biphenyls
  • Marine Biology & Hydrobiology
  • Fundulidae
  • Estrogen Antagonists
  • Enzyme Induction
  • Environmental Exposure
  • Embryonic Development
  • Embryo, Nonmammalian
  • Drug Interactions
  • Dose-Response Relationship, Drug
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wassenberg, D. M., Swails, E. E., & Di Giulio, R. T. (2002). Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus. Marine Environmental Research, 54(3–5), 279–283. https://doi.org/10.1016/s0141-1136(02)00182-4
Wassenberg, Deena M., Erin E. Swails, and Richard T. Di Giulio. “Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus.Marine Environmental Research 54, no. 3–5 (September 2002): 279–83. https://doi.org/10.1016/s0141-1136(02)00182-4.
Wassenberg, Deena M., et al. “Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus.Marine Environmental Research, vol. 54, no. 3–5, Sept. 2002, pp. 279–83. Epmc, doi:10.1016/s0141-1136(02)00182-4.
Wassenberg DM, Swails EE, Di Giulio RT. Effects of single and combined exposures to benzo(a)pyrene and 3,3'4,4'5-pentachlorobiphenyl on EROD activity and development in Fundulus heteroclitus. Marine environmental research. 2002 Sep;54(3–5):279–283.
Journal cover image

Published In

Marine environmental research

DOI

EISSN

1879-0291

ISSN

0141-1136

Publication Date

September 2002

Volume

54

Issue

3-5

Start / End Page

279 / 283

Related Subject Headings

  • Polychlorinated Biphenyls
  • Marine Biology & Hydrobiology
  • Fundulidae
  • Estrogen Antagonists
  • Enzyme Induction
  • Environmental Exposure
  • Embryonic Development
  • Embryo, Nonmammalian
  • Drug Interactions
  • Dose-Response Relationship, Drug