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The acute toxicity and sublethal effects of chlorothalonil in channel catfish (Ictalurus punctatus)

Publication ,  Journal Article
Gallagher, EP; Cattley, RC; Di Giulio, RT
Published in: Chemosphere
January 1, 1992
Published version (DOI)

The in vivo toxicity and sublethal biochemical effects of chlorothalonil (2,4,5,6-tetrachloroisophthalonitrile) were evaluated in the channel catfish (lctalurus punctatus). The static 96hr LC50 value for chlorothalonil was 52 μg/L, indicating that chlorothalonil is highly acutely toxic to channel catfish. Sublethal chlorothalonil exposure for 6 days resulted in acute necrosis of the intestinal epithelial lining in 57% of the treated catfish. However, no treatment-related pathological lesions were observed in liver, gills, posterior kidney, brain, spleen, or heart. Catfish exposed to 13 μg/L chlorothalonil for 72 hr had increased tissue glutathione (GSH) concentrations in liver, posterior kidney and gills, suggesting a protective role of tissue GSH towards chlorothalonil exposure. © 1992.

Duke Scholars

Richard T. Di Giulio
Author Richard T. Di Giulio Environmental Natural Science

Published In

Chemosphere

DOI

10.1016/0045-6535(92)90561-5

ISSN

0045-6535

Publication Date

January 1, 1992

Volume

24

Issue

1

Start / End Page

3 / 10

Related Subject Headings

  • Meteorology & Atmospheric Sciences
  • Environmental Sciences
 

Citation

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MLA
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Gallagher, E. P., Cattley, R. C., & Di Giulio, R. T. (1992). The acute toxicity and sublethal effects of chlorothalonil in channel catfish (Ictalurus punctatus). Chemosphere, 24(1), 3–10. https://doi.org/10.1016/0045-6535(92)90561-5
Gallagher, E. P., R. C. Cattley, and R. T. Di Giulio. “The acute toxicity and sublethal effects of chlorothalonil in channel catfish (Ictalurus punctatus).” Chemosphere 24, no. 1 (January 1, 1992): 3–10. https://doi.org/10.1016/0045-6535(92)90561-5.
Gallagher EP, Cattley RC, Di Giulio RT. The acute toxicity and sublethal effects of chlorothalonil in channel catfish (Ictalurus punctatus). Chemosphere. 1992 Jan 1;24(1):3–10.
Gallagher, E. P., et al. “The acute toxicity and sublethal effects of chlorothalonil in channel catfish (Ictalurus punctatus).” Chemosphere, vol. 24, no. 1, Jan. 1992, pp. 3–10. Scopus, doi:10.1016/0045-6535(92)90561-5.
Gallagher EP, Cattley RC, Di Giulio RT. The acute toxicity and sublethal effects of chlorothalonil in channel catfish (Ictalurus punctatus). Chemosphere. 1992 Jan 1;24(1):3–10.
Journal cover image

Published In

Chemosphere

DOI

10.1016/0045-6535(92)90561-5

ISSN

0045-6535

Publication Date

January 1, 1992

Volume

24

Issue

1

Start / End Page

3 / 10

Related Subject Headings

  • Meteorology & Atmospheric Sciences
  • Environmental Sciences