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Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.

Publication ,  Journal Article
Guerrerio, AL; Colvin, RM; Schwartz, AK; Molleston, JP; Murray, KF; Diehl, A; Mohan, P; Schwimmer, JB; Lavine, JE; Torbenson, MS; Scheimann, AO
Published in: Am J Clin Nutr
April 2012

BACKGROUND: There is significant histologic and biochemical overlap between nonalcoholic fatty liver disease (NAFLD) and steatohepatitis associated with choline deficiency. OBJECTIVE: We sought to determine whether subjects with biopsy-proven NAFLD and evidence of an inadequate intake of choline had more severe histologic features. DESIGN: We performed a cross-sectional analysis of 664 subjects enrolled in the multicenter, prospective Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) with baseline data on diet composition (from a recall-based food-frequency questionnaire) within 6 mo of a liver biopsy. Food questionnaires were analyzed with proprietary software to estimate daily intakes of choline. Liver biopsies were centrally read, and consensus was scored with the NASH CRN-developed scoring system. Because choline needs vary by age, sex, and menopausal status, participants were segregated into corresponding categories (children 9-13 y old, males ≥14 y old, premenopausal women ≥19 y old, and postmenopausal women) on the basis of the Institute of Medicine's definition of adequate intake (AI) for choline. Deficient intake was defined as <50% AI. RESULTS: Postmenopausal women with deficient choline intake had worse fibrosis (P = 0.002) once factors associated with NAFLD (age, race-ethnicity, obesity, elevated triglycerides, diabetes, alcohol use, and steroid use) were considered in multiple ordinal logistic regression models. Choline intake was not identified as a contributor to disease severity in children, men, or premenopausal women. CONCLUSION: Decreased choline intake is significantly associated with increased fibrosis in postmenopausal women with NAFLD. The Pioglitazone vs Vitamin E vs Placebo for Treatment of Non-Diabetic Patients With Nonalcoholic Steatohepatitis trial was registered at clinicaltrials.gov as NCT00063622, and the Treatment of Nonalcoholic Fatty Liver Disease in Children trial was registered at clinicaltrials.gov as NCT00063635.

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Published In

Am J Clin Nutr

DOI

EISSN

1938-3207

Publication Date

April 2012

Volume

95

Issue

4

Start / End Page

892 / 900

Location

United States

Related Subject Headings

  • Young Adult
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Postmenopause
  • Nutrition & Dietetics
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Liver
  • Humans
 

Citation

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Chicago
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Guerrerio, A. L., Colvin, R. M., Schwartz, A. K., Molleston, J. P., Murray, K. F., Diehl, A., … Scheimann, A. O. (2012). Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. Am J Clin Nutr, 95(4), 892–900. https://doi.org/10.3945/ajcn.111.020156
Guerrerio, Anthony L., Ryan M. Colvin, Amy K. Schwartz, Jean P. Molleston, Karen F. Murray, AnnaMae Diehl, Parvathi Mohan, et al. “Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.Am J Clin Nutr 95, no. 4 (April 2012): 892–900. https://doi.org/10.3945/ajcn.111.020156.
Guerrerio AL, Colvin RM, Schwartz AK, Molleston JP, Murray KF, Diehl A, et al. Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. Am J Clin Nutr. 2012 Apr;95(4):892–900.
Guerrerio, Anthony L., et al. “Choline intake in a large cohort of patients with nonalcoholic fatty liver disease.Am J Clin Nutr, vol. 95, no. 4, Apr. 2012, pp. 892–900. Pubmed, doi:10.3945/ajcn.111.020156.
Guerrerio AL, Colvin RM, Schwartz AK, Molleston JP, Murray KF, Diehl A, Mohan P, Schwimmer JB, Lavine JE, Torbenson MS, Scheimann AO. Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. Am J Clin Nutr. 2012 Apr;95(4):892–900.
Journal cover image

Published In

Am J Clin Nutr

DOI

EISSN

1938-3207

Publication Date

April 2012

Volume

95

Issue

4

Start / End Page

892 / 900

Location

United States

Related Subject Headings

  • Young Adult
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Postmenopause
  • Nutrition & Dietetics
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Liver
  • Humans