Cancer stem cells: repair gone awry?
Publication
, Journal Article
Rangwala, F; Omenetti, A; Diehl, AM
Published in: J Oncol
2011
Because cell turnover occurs in all adult organs, stem/progenitor cells within the stem-cell niche of each tissue must be appropriately mobilized and differentiated to maintain normal organ structure and function. Tissue injury increases the demands on this process, and thus may unmask defective regulation of pathways, such as Hedgehog (Hh), that modulate progenitor cell fate. Hh pathway dysregulation has been demonstrated in many types of cancer, including pancreatic and liver cancers, in which defective Hh signaling has been linked to outgrowth of Hh-responsive cancer stem-initiating cells and stromal elements. Hence, the Hh pathway might be a therapeutic target in such tumors.
Duke Scholars
Published In
J Oncol
DOI
EISSN
1687-8469
Publication Date
2011
Volume
2011
Start / End Page
465343
Location
Egypt
Related Subject Headings
- 5203 Clinical and health psychology
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
- 1112 Oncology and Carcinogenesis
- 1108 Medical Microbiology
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Rangwala, F., Omenetti, A., & Diehl, A. M. (2011). Cancer stem cells: repair gone awry? J Oncol, 2011, 465343. https://doi.org/10.1155/2011/465343
Rangwala, Fatima, Alessia Omenetti, and Anna Mae Diehl. “Cancer stem cells: repair gone awry?” J Oncol 2011 (2011): 465343. https://doi.org/10.1155/2011/465343.
Rangwala F, Omenetti A, Diehl AM. Cancer stem cells: repair gone awry? J Oncol. 2011;2011:465343.
Rangwala, Fatima, et al. “Cancer stem cells: repair gone awry?” J Oncol, vol. 2011, 2011, p. 465343. Pubmed, doi:10.1155/2011/465343.
Rangwala F, Omenetti A, Diehl AM. Cancer stem cells: repair gone awry? J Oncol. 2011;2011:465343.
Published In
J Oncol
DOI
EISSN
1687-8469
Publication Date
2011
Volume
2011
Start / End Page
465343
Location
Egypt
Related Subject Headings
- 5203 Clinical and health psychology
- 3211 Oncology and carcinogenesis
- 3202 Clinical sciences
- 1112 Oncology and Carcinogenesis
- 1108 Medical Microbiology
- 1103 Clinical Sciences