Skip to main content
Journal cover image

Dietary composition and nonalcoholic fatty liver disease.

Publication ,  Journal Article
Solga, S; Alkhuraishe, AR; Clark, JM; Torbenson, M; Greenwald, A; Diehl, AM; Magnuson, T
Published in: Dig Dis Sci
October 2004

Nonalcoholic fatty liver disease (NAFLD) is a common and potentially serious form of chronic liver disease that occurs in patients who do not abuse alcohol. Present dietary recommendations for all Americans, including those with NAFLD, endorse a low-calorie, low-fat diet. However, little is known about the effect of diet composition on liver histopathology in patients with NAFLD. The aim of this study was to determine whether overall calorie intake and diet composition are associated with the severity of NAFLD histopathology. Seventy-four consecutive morbidly obese patients presenting for bariatric surgery from January 2001 to March 2002 were retrospectively reviewed. In addition to a standard surgical and psychological evaluation, all patients underwent a preoperative dietary evaluation using a standardized 24-hr food recall. Food intake was evaluated for total calories and macronutrients and compared to liver histopathology from biopsies routinely obtained during surgery. Associations with the severity of steatosis and the presence of inflammation or fibrosis were assessed separately using chi-square for categorical variables and ANOVA for continuous variables. Further, we conducted multiple logistic regression analyses for each histological outcome. There were no significant associations between either total caloric intake or protein intake and either steatosis, fibrosis, or inflammation. However, higher CHO intake was associated with significantly higher odds of inflammation, while higher fat intake was associated with significantly lower odds of inflammation. In conclusion, present dietary recommendations may worsen NAFLD histopathology.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

October 2004

Volume

49

Issue

10

Start / End Page

1578 / 1583

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Obesity, Morbid
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Fatty Liver
  • Dietary Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Solga, S., Alkhuraishe, A. R., Clark, J. M., Torbenson, M., Greenwald, A., Diehl, A. M., & Magnuson, T. (2004). Dietary composition and nonalcoholic fatty liver disease. Dig Dis Sci, 49(10), 1578–1583. https://doi.org/10.1023/b:ddas.0000043367.69470.b7
Solga, Steven, Amir R. Alkhuraishe, Jeanne M. Clark, Mike Torbenson, Ashli Greenwald, Anna Mae Diehl, and Thomas Magnuson. “Dietary composition and nonalcoholic fatty liver disease.Dig Dis Sci 49, no. 10 (October 2004): 1578–83. https://doi.org/10.1023/b:ddas.0000043367.69470.b7.
Solga S, Alkhuraishe AR, Clark JM, Torbenson M, Greenwald A, Diehl AM, et al. Dietary composition and nonalcoholic fatty liver disease. Dig Dis Sci. 2004 Oct;49(10):1578–83.
Solga, Steven, et al. “Dietary composition and nonalcoholic fatty liver disease.Dig Dis Sci, vol. 49, no. 10, Oct. 2004, pp. 1578–83. Pubmed, doi:10.1023/b:ddas.0000043367.69470.b7.
Solga S, Alkhuraishe AR, Clark JM, Torbenson M, Greenwald A, Diehl AM, Magnuson T. Dietary composition and nonalcoholic fatty liver disease. Dig Dis Sci. 2004 Oct;49(10):1578–1583.
Journal cover image

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

October 2004

Volume

49

Issue

10

Start / End Page

1578 / 1583

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Obesity, Morbid
  • Middle Aged
  • Male
  • Logistic Models
  • Humans
  • Gastroenterology & Hepatology
  • Female
  • Fatty Liver
  • Dietary Proteins