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Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease.

Publication ,  Journal Article
Diehl, AM
Published in: Clin Liver Dis
August 2004

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of hepatic pathology that resembles alcohol-induced fatty liver disease(AFLD), but which develops in individuals who are not heavy drinkers. In people, NAFLD is associated strongly with obesity,insulin resistance, and dysmetabolic syndrome, but the exact mechanisms that promote liver disease in this clinical context remain poorly understood. The proinflammatory cytokine, funor necrosis factor alpha is known to be a key mediator of AFLD. This article discusses clinical and experimental evidence that tumor necrosis factor plays a role in the pathogenesis of insulin resistance syndromes, including nonalcoholic fatty syndromes, including nonalcoholic fatty liver disease.

Duke Scholars

Published In

Clin Liver Dis

DOI

ISSN

1089-3261

Publication Date

August 2004

Volume

8

Issue

3

Start / End Page

619 / x

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Obesity
  • Mice, Inbred NOD
  • Mice
  • Insulin Resistance
  • Humans
  • Gastroenterology & Hepatology
  • Fatty Liver
  • Animals
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diehl, A. M. (2004). Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease. Clin Liver Dis, 8(3), 619–x. https://doi.org/10.1016/j.cld.2004.04.012
Diehl, Anna Mae. “Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease.Clin Liver Dis 8, no. 3 (August 2004): 619–x. https://doi.org/10.1016/j.cld.2004.04.012.
Diehl, Anna Mae. “Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease.Clin Liver Dis, vol. 8, no. 3, Aug. 2004, pp. 619–x. Pubmed, doi:10.1016/j.cld.2004.04.012.
Journal cover image

Published In

Clin Liver Dis

DOI

ISSN

1089-3261

Publication Date

August 2004

Volume

8

Issue

3

Start / End Page

619 / x

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Obesity
  • Mice, Inbred NOD
  • Mice
  • Insulin Resistance
  • Humans
  • Gastroenterology & Hepatology
  • Fatty Liver
  • Animals
  • 3202 Clinical sciences