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Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells.

Publication ,  Journal Article
Oben, JA; Yang, S; Lin, H; Ono, M; Diehl, AM
Published in: Biochem Biophys Res Commun
January 3, 2003

The mechanisms that initiate and perpetuate the fibrogenic response, during liver injury, are unclear. Animal studies, however, strongly support a role for the autonomic nervous system (ANS) in wound healing. Therefore, the ANS may also mediate the development of cirrhosis. Hepatic stellate cells (HSC), the liver's major matrix-producing cells, are activated by injury to become proliferative, fibrogenic myofibroblasts. HSC respond to sympathetic neurotransmitters by changing phenotype, suggesting that HSC may be the cellular effectors of ANS signals that modulate hepatic fibrogenesis during recovery from liver damage. We show here that the parasympathetic neurotransmitter acetylcholine markedly stimulates the proliferation of myofibroblastic HSC and induces HSC collagen gene expression in these cells. By extending evidence that HSC are direct targets of the ANS, these results support the proposed neuroglial role of HSC in the liver and suggest that interrupting ANS signalling may be useful in constraining the fibrogenic response to liver injury.

Duke Scholars

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

January 3, 2003

Volume

300

Issue

1

Start / End Page

172 / 177

Location

United States

Related Subject Headings

  • Mice, Inbred C57BL
  • Mice
  • Liver Cirrhosis
  • Liver
  • In Vitro Techniques
  • Gene Expression
  • Fibroblasts
  • Collagen
  • Cell Division
  • Biochemistry & Molecular Biology
 

Citation

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Oben, J. A., Yang, S., Lin, H., Ono, M., & Diehl, A. M. (2003). Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells. Biochem Biophys Res Commun, 300(1), 172–177. https://doi.org/10.1016/s0006-291x(02)02773-0
Oben, Jude A., Shiqi Yang, Huizhi Lin, Mafasumi Ono, and Anna Mae Diehl. “Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells.Biochem Biophys Res Commun 300, no. 1 (January 3, 2003): 172–77. https://doi.org/10.1016/s0006-291x(02)02773-0.
Oben JA, Yang S, Lin H, Ono M, Diehl AM. Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells. Biochem Biophys Res Commun. 2003 Jan 3;300(1):172–7.
Oben, Jude A., et al. “Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells.Biochem Biophys Res Commun, vol. 300, no. 1, Jan. 2003, pp. 172–77. Pubmed, doi:10.1016/s0006-291x(02)02773-0.
Oben JA, Yang S, Lin H, Ono M, Diehl AM. Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells. Biochem Biophys Res Commun. 2003 Jan 3;300(1):172–177.
Journal cover image

Published In

Biochem Biophys Res Commun

DOI

ISSN

0006-291X

Publication Date

January 3, 2003

Volume

300

Issue

1

Start / End Page

172 / 177

Location

United States

Related Subject Headings

  • Mice, Inbred C57BL
  • Mice
  • Liver Cirrhosis
  • Liver
  • In Vitro Techniques
  • Gene Expression
  • Fibroblasts
  • Collagen
  • Cell Division
  • Biochemistry & Molecular Biology