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Roles of CCAAT/enhancer-binding proteins in regulation of liver regenerative growth.

Publication ,  Journal Article
Diehl, AM
Published in: J Biol Chem
November 20, 1998

The expressions and activities of several CCAAT/enhancer-binding proteins (C/EBP) isoforms fluctuate in the regenerating liver. The physiological implications of these variations in C/EBP function remain poorly characterized in the setting of regeneration. However, lessons learned in various hepatocyte cell lines and by studying primary hepatocytes from transgenic C/EBPalpha-deficient mice suggest that the C/EBP isoforms are likely to influence proliferation, differentiated gene expression, and survival in mature, adult hepatocytes. In addition, these factors are potentially important modulators of liver nonparenchymal cell genes, including those that encode matrix molecules and growth factors that are required for successful liver regeneration. The possibility that members of the C/EBP family of transcription factors actively participate in many aspects of the regenerative response to liver injury is strengthened by growing evidence that many hepatocyte mitogens and co-mitogens regulate C/EBP activity. Furthermore, the C/EBPs themselves appear to regulate the expression of some of these growth regulators.

Duke Scholars

Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

November 20, 1998

Volume

273

Issue

47

Start / End Page

30843 / 30846

Location

United States

Related Subject Headings

  • Protein Binding
  • Nuclear Proteins
  • Liver Regeneration
  • Liver
  • Humans
  • Enhancer Elements, Genetic
  • DNA-Binding Proteins
  • Cell Division
  • CCAAT-Enhancer-Binding Proteins
  • Biochemistry & Molecular Biology
 

Citation

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Diehl, A. M. (1998). Roles of CCAAT/enhancer-binding proteins in regulation of liver regenerative growth. J Biol Chem, 273(47), 30843–30846. https://doi.org/10.1074/jbc.273.47.30843
Diehl, A. M. “Roles of CCAAT/enhancer-binding proteins in regulation of liver regenerative growth.J Biol Chem 273, no. 47 (November 20, 1998): 30843–46. https://doi.org/10.1074/jbc.273.47.30843.
Diehl, A. M. “Roles of CCAAT/enhancer-binding proteins in regulation of liver regenerative growth.J Biol Chem, vol. 273, no. 47, Nov. 1998, pp. 30843–46. Pubmed, doi:10.1074/jbc.273.47.30843.
Diehl AM. Roles of CCAAT/enhancer-binding proteins in regulation of liver regenerative growth. J Biol Chem. 1998 Nov 20;273(47):30843–30846.

Published In

J Biol Chem

DOI

ISSN

0021-9258

Publication Date

November 20, 1998

Volume

273

Issue

47

Start / End Page

30843 / 30846

Location

United States

Related Subject Headings

  • Protein Binding
  • Nuclear Proteins
  • Liver Regeneration
  • Liver
  • Humans
  • Enhancer Elements, Genetic
  • DNA-Binding Proteins
  • Cell Division
  • CCAAT-Enhancer-Binding Proteins
  • Biochemistry & Molecular Biology