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Alcoholic liver disease.

Publication ,  Journal Article
Diehl, AM
Published in: Clin Liver Dis
February 1998

Alcohol has been implicated in the genesis of liver disease for centuries. Significant progress has been made in our understanding of the pathogenesis of ALD. It is now apparent that both the consumption and the metabolism of alcohol promote the production of inflammatory mediators (cytokines) that result in hepatotoxicity and fibrogenesis. With time, this leads to progressively severe liver injury and, eventually, causes cirrhosis. Unfortunately, effective therapies for most individuals with ALD have not been found. High per capita consumption of alcohol, coupled with the dearth of effective treatments and the failure of most affected individuals to abstain from alcohol, explains why ALD is one of the most prevalent forms of disabling, chronic liver disease in the United States.

Duke Scholars

Published In

Clin Liver Dis

DOI

ISSN

1089-3261

Publication Date

February 1998

Volume

2

Issue

1

Start / End Page

103 / 118

Location

United States

Related Subject Headings

  • Liver Diseases, Alcoholic
  • Humans
  • Gastroenterology & Hepatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Diehl, A. M. (1998). Alcoholic liver disease. Clin Liver Dis, 2(1), 103–118. https://doi.org/10.1016/s1089-3261(05)70366-4
Diehl, A. M. “Alcoholic liver disease.Clin Liver Dis 2, no. 1 (February 1998): 103–18. https://doi.org/10.1016/s1089-3261(05)70366-4.
Diehl AM. Alcoholic liver disease. Clin Liver Dis. 1998 Feb;2(1):103–18.
Diehl, A. M. “Alcoholic liver disease.Clin Liver Dis, vol. 2, no. 1, Feb. 1998, pp. 103–18. Pubmed, doi:10.1016/s1089-3261(05)70366-4.
Diehl AM. Alcoholic liver disease. Clin Liver Dis. 1998 Feb;2(1):103–118.
Journal cover image

Published In

Clin Liver Dis

DOI

ISSN

1089-3261

Publication Date

February 1998

Volume

2

Issue

1

Start / End Page

103 / 118

Location

United States

Related Subject Headings

  • Liver Diseases, Alcoholic
  • Humans
  • Gastroenterology & Hepatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences