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REVIEW: Regulation of liver regeneration by pro-inflammatory cytokines

Publication ,  Journal Article
Diehl, AM; Rai, R
Published in: Journal of Gastroenterology and Hepatology (Australia)
January 1, 1996

The liver has tremendous regenerative capacity. This distinguishes it from other vital organs (e.g. the brain, heart and lungs) that cannot replace functional tissue once it has been destroyed. Although hepatocytes rarely proliferate in the healthy adult liver, virtually all surviving: hepatocytes replicate at least once after 70% partial hepatectomy. Therefore, partial liver resection has been used to characterize mechanisms that regulate liver regeneration. Residual hepatocytes up-regulate both proliferative and liver-specific gene expression in order to preserve tissue specific function. In addition, hepatocyte proliferation is tightly co-ordinated to complement regenerative responses in hepatic nonparenchymal cells (e.g. endothelia, biliary epithelia, stellate and Kupffer cells), so that the entire organ can be reconstituted within days. Studies with neutralizing antibodies to tumour necrosis factor-α (TNF) clearly demonstrate that, after partial hepatectomy, TNF promotes liver cell proliferation. The present review focuses on the regulation of the hepatocyte proliferative response by pro-inflammatory cytokines.

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Published In

Journal of Gastroenterology and Hepatology (Australia)

DOI

ISSN

0815-9319

Publication Date

January 1, 1996

Volume

11

Issue

5

Start / End Page

466 / 470

Related Subject Headings

  • Gastroenterology & Hepatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Diehl, A. M., & Rai, R. (1996). REVIEW: Regulation of liver regeneration by pro-inflammatory cytokines. Journal of Gastroenterology and Hepatology (Australia), 11(5), 466–470. https://doi.org/10.1111/j.1440-1746.1996.tb00292.x
Diehl, A. M., and R. Rai. “REVIEW: Regulation of liver regeneration by pro-inflammatory cytokines.” Journal of Gastroenterology and Hepatology (Australia) 11, no. 5 (January 1, 1996): 466–70. https://doi.org/10.1111/j.1440-1746.1996.tb00292.x.
Diehl AM, Rai R. REVIEW: Regulation of liver regeneration by pro-inflammatory cytokines. Journal of Gastroenterology and Hepatology (Australia). 1996 Jan 1;11(5):466–70.
Diehl, A. M., and R. Rai. “REVIEW: Regulation of liver regeneration by pro-inflammatory cytokines.” Journal of Gastroenterology and Hepatology (Australia), vol. 11, no. 5, Jan. 1996, pp. 466–70. Scopus, doi:10.1111/j.1440-1746.1996.tb00292.x.
Diehl AM, Rai R. REVIEW: Regulation of liver regeneration by pro-inflammatory cytokines. Journal of Gastroenterology and Hepatology (Australia). 1996 Jan 1;11(5):466–470.
Journal cover image

Published In

Journal of Gastroenterology and Hepatology (Australia)

DOI

ISSN

0815-9319

Publication Date

January 1, 1996

Volume

11

Issue

5

Start / End Page

466 / 470

Related Subject Headings

  • Gastroenterology & Hepatology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences