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Alcohol and cytokine-inducible transcription factors.

Publication ,  Journal Article
Zeldin, G; Yang, SQ; Yin, M; Lin, HZ; Rai, R; Diehl, AM
Published in: Alcohol Clin Exp Res
December 1996

Cytokines, such as TNF alpha, modulate the behavior of many cells by regulating the expression of a wide array of genes. When a cytokine binds to its receptor on the cell surface, the receptor becomes activated and activates signal transduction cascades. These cascades typically involve a series of phosphorylation reactions that lead to sequential activation of various kinases. The targets of these kinases include DNA binding proteins that regulate the transcription of target genes. The activity of DNA binding proteins, such as c-Jun and NF-kappa B, titrates the transcriptional activity of cytokine-regulated genes. Both acute and chronic alcohol consumption of ethanol increase hepatic expression of TNF alpha. After acute ethanol consumption, this is associated with increased induction of several TNF-dependent regenerative events, including the activation of c-Jun and increased binding activity of NF-kappa B. However, chronic consumption of ethanol appears to impede TNF alpha signaling in the liver because it attenuates the increases in c-JUN activity and NF-kappa B binding, which normally follow partial hepatectomy. These results suggest that one mechanism by which ethanol influences liver cell behavior is by influencing local expression of TNF alpha and changing the activity of TNF-regulated transcription factors.

Duke Scholars

Published In

Alcohol Clin Exp Res

DOI

ISSN

0145-6008

Publication Date

December 1996

Volume

20

Issue

9

Start / End Page

1639 / 1645

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transcriptional Activation
  • Transcription Factors
  • Substance Abuse
  • Signal Transduction
  • Rats
  • Proto-Oncogene Proteins c-jun
  • NF-kappa B
  • Liver Regeneration
  • Liver
 

Citation

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ICMJE
MLA
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Zeldin, G., Yang, S. Q., Yin, M., Lin, H. Z., Rai, R., & Diehl, A. M. (1996). Alcohol and cytokine-inducible transcription factors. Alcohol Clin Exp Res, 20(9), 1639–1645. https://doi.org/10.1111/j.1530-0277.1996.tb01710.x
Zeldin, G., S. Q. Yang, M. Yin, H. Z. Lin, R. Rai, and A. M. Diehl. “Alcohol and cytokine-inducible transcription factors.Alcohol Clin Exp Res 20, no. 9 (December 1996): 1639–45. https://doi.org/10.1111/j.1530-0277.1996.tb01710.x.
Zeldin G, Yang SQ, Yin M, Lin HZ, Rai R, Diehl AM. Alcohol and cytokine-inducible transcription factors. Alcohol Clin Exp Res. 1996 Dec;20(9):1639–45.
Zeldin, G., et al. “Alcohol and cytokine-inducible transcription factors.Alcohol Clin Exp Res, vol. 20, no. 9, Dec. 1996, pp. 1639–45. Pubmed, doi:10.1111/j.1530-0277.1996.tb01710.x.
Zeldin G, Yang SQ, Yin M, Lin HZ, Rai R, Diehl AM. Alcohol and cytokine-inducible transcription factors. Alcohol Clin Exp Res. 1996 Dec;20(9):1639–1645.
Journal cover image

Published In

Alcohol Clin Exp Res

DOI

ISSN

0145-6008

Publication Date

December 1996

Volume

20

Issue

9

Start / End Page

1639 / 1645

Location

England

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Transcriptional Activation
  • Transcription Factors
  • Substance Abuse
  • Signal Transduction
  • Rats
  • Proto-Oncogene Proteins c-jun
  • NF-kappa B
  • Liver Regeneration
  • Liver