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The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.

Publication ,  Journal Article
Jacq, C; Alt-Mörbe, J; Andre, B; Arnold, W; Bahr, A; Ballesta, JP; Bargues, M; Baron, L; Becker, A; Biteau, N; Blöcker, H; Blugeon, C ...
Published in: Nature
May 29, 1997

The complete DNA sequence of the yeast Saccharomyces cerevisiae chromosome IV has been determined. Apart from chromosome XII, which contains the 1-2 Mb rDNA cluster, chromosome IV is the longest S. cerevisiae chromosome. It was split into three parts, which were sequenced by a consortium from the European Community, the Sanger Centre, and groups from St Louis and Stanford in the United States. The sequence of 1,531,974 base pairs contains 796 predicted or known genes, 318 (39.9%) of which have been previously identified. Of the 478 new genes, 225 (28.3%) are homologous to previously identified genes and 253 (32%) have unknown functions or correspond to spurious open reading frames (ORFs). On average there is one gene approximately every two kilobases. Superimposed on alternating regional variations in G+C composition, there is a large central domain with a lower G+C content that contains all the yeast transposon (Ty) elements and most of the tRNA genes. Chromosome IV shares with chromosomes II, V, XII, XIII and XV some long clustered duplications which partly explain its origin.

Duke Scholars

Published In

Nature

ISSN

0028-0836

Publication Date

May 29, 1997

Volume

387

Issue

6632 Suppl

Start / End Page

75 / 78

Location

England

Related Subject Headings

  • Saccharomyces cerevisiae
  • Molecular Sequence Data
  • General Science & Technology
  • DNA, Fungal
  • Chromosomes, Fungal
  • Base Sequence
 

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Jacq, C., Alt-Mörbe, J., Andre, B., Arnold, W., Bahr, A., Ballesta, J. P., … Zaccaria, P. (1997). The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Nature, 387(6632 Suppl), 75–78.
Jacq, C., J. Alt-Mörbe, B. Andre, W. Arnold, A. Bahr, J. P. Ballesta, M. Bargues, et al. “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.Nature 387, no. 6632 Suppl (May 29, 1997): 75–78.
Jacq C, Alt-Mörbe J, Andre B, Arnold W, Bahr A, Ballesta JP, et al. The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Nature. 1997 May 29;387(6632 Suppl):75–8.
Jacq, C., et al. “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.Nature, vol. 387, no. 6632 Suppl, May 1997, pp. 75–78.
Jacq C, Alt-Mörbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Blöcker H, Blugeon C, Boskovic J, Brandt P, Brückner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P. The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Nature. 1997 May 29;387(6632 Suppl):75–78.
Journal cover image

Published In

Nature

ISSN

0028-0836

Publication Date

May 29, 1997

Volume

387

Issue

6632 Suppl

Start / End Page

75 / 78

Location

England

Related Subject Headings

  • Saccharomyces cerevisiae
  • Molecular Sequence Data
  • General Science & Technology
  • DNA, Fungal
  • Chromosomes, Fungal
  • Base Sequence