Scholars@Duke publication: Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.

Publication , Journal Article

Mirotsou, M; Zhang, Z; Deb, A; Zhang, L; Gnecchi, M; Noiseux, N; Mu, H; Pachori, A; Dzau, V

Published in: Proc Natl Acad Sci U S A

January 30, 2007

Stem cell therapy has emerged as a promising tool for the treatment of a variety of diseases. Previously, we have shown that Akt-modified mesenchymal stem cells mediate tissue repair through paracrine mechanisms. Using a comprehensive functional genomic strategy, we show that secreted frizzled related protein 2 (Sfrp2) is the key stem cell paracrine factor that mediates myocardial survival and repair after ischemic injury. Sfrp2 is known to modulate Wnt signaling, and we demonstrate that cardiomyocytes treated with secreted frizzled related protein increase cellular beta-catenin and up-regulate expression of antiapoptotic genes. These findings reveal the key role played by Sfrp2 in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair and identify modulation of Wnt signaling as a therapeutic target for heart disease.

Duke Scholars

Author Victor J. Dzau Medicine, Cardiology

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.0610024104

ISSN

0027-8424

Publication Date

January 30, 2007

Volume

104

Issue

Start / End Page

1643 / 1648

Location

United States

Related Subject Headings

beta Catenin
Up-Regulation
Stem Cells
Signal Transduction
Rats, Sprague-Dawley
Rats
Proto-Oncogene Proteins c-akt
Myocytes, Cardiac
Myocardium
Mice, Inbred C57BL

Citation

APA

Chicago

ICMJE

MLA

NLM

Mirotsou, M., Zhang, Z., Deb, A., Zhang, L., Gnecchi, M., Noiseux, N., … Dzau, V. (2007). Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci U S A, 104(5), 1643–1648. https://doi.org/10.1073/pnas.0610024104

Mirotsou, Maria, Zhongyan Zhang, Arjun Deb, Lunan Zhang, Massimiliano Gnecchi, Nicolas Noiseux, Hui Mu, Alok Pachori, and Victor Dzau. “Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.” Proc Natl Acad Sci U S A 104, no. 5 (January 30, 2007): 1643–48. https://doi.org/10.1073/pnas.0610024104.

Mirotsou M, Zhang Z, Deb A, Zhang L, Gnecchi M, Noiseux N, et al. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1643–8.

Mirotsou, Maria, et al. “Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.” Proc Natl Acad Sci U S A, vol. 104, no. 5, Jan. 2007, pp. 1643–48. Pubmed, doi:10.1073/pnas.0610024104.

Mirotsou M, Zhang Z, Deb A, Zhang L, Gnecchi M, Noiseux N, Mu H, Pachori A, Dzau V. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1643–1648.