Skip to main content

Gene inhibition and gene augmentation for the treatment of vascular proliferative disorders.

Publication ,  Journal Article
von der Leyen, HE; Mann, MJ; Dzau, VJ
Published in: Semin Interv Cardiol
September 1996

Gene therapy is emerging as a potential strategy for the treatment of vasculoproliferative diseases such as restenosis after angioplasty, vascular bypass graft occlusion and transplant coronary vasculopathy for which no known effective therapy exists. Our laboratory has demonstrated that vascular smooth muscle proliferation and lesion formation can be prevented by the blockade of genes regulating cell cycle progression. With this approach it was also shown that genetically engineered bioprostheses can be developed that are resistant to accelerated atherosclerosis and thus to graft failure. We have also reported that the direct in vivo transfer of a cDNA encoding endothelial nitric oxide synthase resulted in inhibition of neointimal lesion formation and improvement of vascular reactivity, demonstrating that therapeutic effects can also be achieved by the in vivo transfer of gene(s) whose product(s) exert a paracrine effect on the vessel wall.

Duke Scholars

Published In

Semin Interv Cardiol

ISSN

1084-2764

Publication Date

September 1996

Volume

1

Issue

3

Start / End Page

209 / 214

Location

England

Related Subject Headings

  • Secondary Prevention
  • Rats
  • Rabbits
  • RNA, Messenger
  • Oligonucleotides, Antisense
  • Humans
  • Genetic Therapy
  • Gene Transfer Techniques
  • Gene Expression
  • Endothelium, Vascular
 

Citation

APA
Chicago
ICMJE
MLA
NLM
von der Leyen, H. E., Mann, M. J., & Dzau, V. J. (1996). Gene inhibition and gene augmentation for the treatment of vascular proliferative disorders. Semin Interv Cardiol, 1(3), 209–214.
Leyen, H. E. von der, M. J. Mann, and V. J. Dzau. “Gene inhibition and gene augmentation for the treatment of vascular proliferative disorders.Semin Interv Cardiol 1, no. 3 (September 1996): 209–14.
von der Leyen HE, Mann MJ, Dzau VJ. Gene inhibition and gene augmentation for the treatment of vascular proliferative disorders. Semin Interv Cardiol. 1996 Sep;1(3):209–14.
von der Leyen, H. E., et al. “Gene inhibition and gene augmentation for the treatment of vascular proliferative disorders.Semin Interv Cardiol, vol. 1, no. 3, Sept. 1996, pp. 209–14.
von der Leyen HE, Mann MJ, Dzau VJ. Gene inhibition and gene augmentation for the treatment of vascular proliferative disorders. Semin Interv Cardiol. 1996 Sep;1(3):209–214.

Published In

Semin Interv Cardiol

ISSN

1084-2764

Publication Date

September 1996

Volume

1

Issue

3

Start / End Page

209 / 214

Location

England

Related Subject Headings

  • Secondary Prevention
  • Rats
  • Rabbits
  • RNA, Messenger
  • Oligonucleotides, Antisense
  • Humans
  • Genetic Therapy
  • Gene Transfer Techniques
  • Gene Expression
  • Endothelium, Vascular