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Vascular renin-angiotensin system and vascular protection.

Publication ,  Journal Article
Dzau, VJ
Published in: J Cardiovasc Pharmacol
1993

Vascular angiotensin plays an important role in the long-term regulation of the blood vessel function and structure. Angiotensin stimulates vascular smooth-muscle cell growth via the induction of protooncogene and autocrine growth factor gene expressions. In hypertension, atherosclerosis and restenosis, vascular angiotensin activity is increased and participates in the pathobiology of these vascular diseases. Experimental data demonstrate that angiotensin-converting enzyme inhibitors can prevent vascular hypertrophy of hypertension, attenuate atherosclerosis, and inhibit neointimal hyperplasia of restenosis. Taken together, the data show that pharmacologic blockade of the vascular renin-angiotensin system may result in vascular protection. Ongoing clinical trials (MERCATOR, QUIET) will address the relevance of these experimental observations in clinical therapy.

Duke Scholars

Published In

J Cardiovasc Pharmacol

DOI

ISSN

0160-2446

Publication Date

1993

Volume

22 Suppl 5

Start / End Page

S1 / S9

Location

United States

Related Subject Headings

  • Vascular Diseases
  • Renin-Angiotensin System
  • Peptidyl-Dipeptidase A
  • Muscle, Smooth, Vascular
  • Humans
  • Clinical Trials as Topic
  • Cell Division
  • Cardiovascular System & Hematology
  • Blood Vessels
  • Angiotensin-Converting Enzyme Inhibitors
 

Citation

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MLA
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Dzau, V. J. (1993). Vascular renin-angiotensin system and vascular protection. J Cardiovasc Pharmacol, 22 Suppl 5, S1–S9. https://doi.org/10.1097/00005344-199322005-00002
Dzau, V. J. “Vascular renin-angiotensin system and vascular protection.J Cardiovasc Pharmacol 22 Suppl 5 (1993): S1–9. https://doi.org/10.1097/00005344-199322005-00002.
Dzau VJ. Vascular renin-angiotensin system and vascular protection. J Cardiovasc Pharmacol. 1993;22 Suppl 5:S1–9.
Dzau, V. J. “Vascular renin-angiotensin system and vascular protection.J Cardiovasc Pharmacol, vol. 22 Suppl 5, 1993, pp. S1–9. Pubmed, doi:10.1097/00005344-199322005-00002.
Dzau VJ. Vascular renin-angiotensin system and vascular protection. J Cardiovasc Pharmacol. 1993;22 Suppl 5:S1–S9.

Published In

J Cardiovasc Pharmacol

DOI

ISSN

0160-2446

Publication Date

1993

Volume

22 Suppl 5

Start / End Page

S1 / S9

Location

United States

Related Subject Headings

  • Vascular Diseases
  • Renin-Angiotensin System
  • Peptidyl-Dipeptidase A
  • Muscle, Smooth, Vascular
  • Humans
  • Clinical Trials as Topic
  • Cell Division
  • Cardiovascular System & Hematology
  • Blood Vessels
  • Angiotensin-Converting Enzyme Inhibitors